Integrative And Translational Biomedical Engineering

综合与转化生物医学工程

• 批准号: CRC-2018-00085
• 负责人: Juncker, David
• 金额: $ 14.57万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Canada Research Chairs
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=730348
• 关键词: Integrative; Translational; Biomedical; Engineering

Multiomic analysis is empowering precision medicine and is leading to a new paradigm of preventative and prognostic medicine integrating omic and physiological data. Extracellular vesicles and (rare) circulating cells carry the molecular fingerprints of their origin, and provide context-rich information, but are not considered. Here, Dr. Juncker proposes a trimodal analysis platform capturing protein, extracellular vesicles, and rare circulating cells using technologies developed in his lab. The trimodal analysis will be optimized and validated with breast and metastatic liver cancer patients. Trimodal analysis will enhance multiomic analysis, lead to more accurate prognosis, earlier diagnosis, and eventually preventative medicine.

多组学分析正在赋予精准医学以力量，并正在引领一种整合组学和生理学数据的预防和预后医学的新范式。细胞外囊泡和（罕见的）循环细胞携带其来源的分子指纹，并提供丰富的上下文信息，但不被考虑。在这里，Juncker博士提出了一个三峰分析平台，使用他的实验室开发的技术捕获蛋白质，细胞外囊泡和稀有循环细胞。三峰分析将在乳腺癌和转移性肝癌患者中进行优化和验证。三模式分析将加强多组学分析，导致更准确的预后，早期诊断，并最终预防医学。