Chromatin and Epigenetics

 描述(由申请人提供)：请求支持由Luciano Di Croce和杨石组织的题为染色质和表观遗传学的Keystone研讨会。会议将于2016年3月20日至24日在加拿大不列颠哥伦比亚省惠斯勒举行。真核细胞的DNA被组织成染色质纤维，其中核小体是基本的重复单位。因此，染色质是基因调控、干细胞命运决定和癌症等基本过程的核心。大体上，这些议题传统上是通过单独的会议来讨论的。然而，最近的文献表明，这些不同学科之间的界限正在变得不那么清楚。这次会议将汇集研究染色质结构、表观遗传学、干细胞生物学和癌症的科学家。讲座将涵盖广泛的主题，包括染色体组织、远程相互作用、染色质组装、干细胞调控/分化、基于RNA的机制和转录调控。选定发言者是为了广泛反映从各种模式生物体和实验方法中吸取的经验教训。初级科学家将能够通过从提交的摘要中挑选的大量简短演讲以及通过海报演示来展示他们的工作。在每一次会议结束时，还将有足够的时间交流意见和讨论新的假设，以及非正式互动和建立网络的时间。这次会议与NCI的任务相关，因为它的重点是染色质和下一代表观遗传药物。事实上，由NCI和NHGRI联合管理的癌症基因组图谱包括表观基因组学组成部分。

 DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Chromatin and Epigenetics, organized by Luciano Di Croce and Yang Shi. The meeting will be held in Whistler, BC, Canada from March 20-24, 2016. The DNA of eukaryotic cells is organized into chromatin fibers, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting will bring together scientists studying chromatin structure, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organization, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms and transcription regulation. Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Junior scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. There will also be ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking. This meeting is relevant to the NCI mission because of its focus on chromatin and next generation epigenetic drugs. Indeed, The Cancer Genome Atlas, which is jointly administered by NCI and NHGRI, includes an epigenomics component.