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Chromatin and Epigenetics

染色质和表观遗传学

基本信息

批准号：
9106870
负责人：
DAVID L. WOODLAND
金额：
$ 0.4万
依托单位：
KEYSTONE SYMPOSIA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2016-11-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9106870
关键词：
Animal Model Attention Canada Chromatin Chromatin Fiber Chromatin Modeling Chromatin Structure Chromosome Structures Collaborations DNA Discipline Educational workshop Epigenetic Process Eukaryotic Cell Feedback Fostering Gene Expression Regulation Genetic Transcription Genomic approach Health Human Inherited International Knowledge Learning Literature Malignant Neoplasms Methodology Mission National Human Genome Research Institute Nucleosomes Outcome Process RNA Regulation Research Research Personnel Role Scientist Signal Transduction Stem cells The Cancer Genome Atlas Time Transcriptional Regulation Work Yang abstracting base clinical practice enzyme activity epigenetic drug epigenomics histone modification human disease inter-institutional meetings next generation novel posters public health relevance response stem cell biology stem cell fate symposium

项目摘要

DESCRIPTION (provided by applicant): Support is requested for a Keystone Symposia meeting entitled Chromatin and Epigenetics, organized by Luciano Di Croce and Yang Shi. The meeting will be held in Whistler, BC, Canada from March 20-24, 2016. The DNA of eukaryotic cells is organized into chromatin fibers, where the nucleosome is the basic repeating unit. Chromatin is thus at the core of fundamental processes such as gene regulation, stem cell fate determination and cancer. By and large, these topics have traditionally been covered by separated meetings. However, recent literature indicates that the boundaries among these various disciplines are becoming less clear. This meeting will bring together scientists studying chromatin structure, epigenetics, stem cell biology and cancer. The talks will cover a broad range of topics, including chromosome organization, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms and transcription regulation. Speakers have been selected to broadly reflect lessons learned from a variety of model organisms and experimental approaches. Junior scientists will be able to present their work through a large number of short talks selected from submitted abstracts as well as through poster presentation. There will also be ample time for exchanging ideas and discussing novel hypothesis at the end of each session, as well as time for informal interactions and networking. This meeting is relevant to the NCI mission because of its focus on chromatin and next generation epigenetic drugs. Indeed, The Cancer Genome Atlas, which is jointly administered by NCI and NHGRI, includes an epigenomics component.