A Modular Continuous Flow System for the Synthesis of Molecules and Materials

用于分子和材料合成的模块化连续流系统

• 批准号: RTI-2022-00385
• 负责人: Leitch, David
• 金额: $ 10.93万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=741753
• 关键词: Modular; Continuous; Flow; System; Synthesis

Continuous flow chemical synthesis is poised to revolutionize both the way that pharmaceuticals and advanced materials are manufactured, and the way we use artificial intelligence and robotics for exploring chemical reactivity. Relative to traditional batch synthesis, flow synthesis provides more precise control over the reaction conditions, more reliable monitoring of a reaction's progress, better containment of highly hazardous materials, the ability to directly flow the products of one chemical reaction into a subsequent reaction, and the opportunity to automate many operational aspects. Because of these clear advantages, many industries (particularly the pharmaceutical and agrochemical industries) are adopting these new technologies. Yet the use of continuous flow tools and techniques is still rare in academic research labs. The Leitch, Manners, McIndoe, Rosenberg, and Wulff groups at the University of Victoria urgently require continuous flow capabilities to tackle problems as diverse as chemical reaction development, synthesis of new biologically active molecules, understanding chemical reactivity for complex processes, building automated systems for chemical synthesis, and creating next generation polymer and nanoparticle materials. This proposal seeks funding for a modular, custom laboratory flow chemistry system capable of achieving a wide range of reaction conditions and scales. The proposed equipment can operate with everything from milligrams of material undergoing reactions in seconds through to kilogram scale synthesis over multiple days of continuous operation, all in the space of a standard laboratory bench. This instrument will enable the applicant groups to explore entirely new avenues of research that are not possible using traditional means. These include devising methods to continuously analyze chemical reactions using multiple simultaneous techniques, studying the course of chemical reactions under extreme conditions, safely generating and handling highly reactive and potentially hazardous chemical intermediates en route to new products, and developing scalable continuous flow syntheses of key anti-cancer and anti-infective medicines as a bulwark against future drug shortages in Canada. The proposed flow chemistry system is a foundational tool for the recently established Leitch group, and represents a unique training opportunity for all researchers at UVic. As industries increasingly rely on continuous and automated manufacturing for fine chemicals and pharmaceuticals, it is imperative that our students become adept at using flow chemistry techniques and tools. This will enable researchers from our groups to be leaders in developing and implementing new continuous flow technologies.

连续流化学合成有望彻底改变药物和先进材料的制造方式，以及我们使用人工智能和机器人技术探索化学反应性的方式。相对于传统的分批合成，流动合成提供了对反应条件的更精确的控制、对反应进程的更可靠的监测、对高度危险的材料的更好的遏制、将一个化学反应的产物直接流入后续反应的能力，以及使许多操作方面自动化的机会。由于这些明显的优势，许多行业（特别是制药和农用化学品行业）正在采用这些新技术。然而，在学术研究实验室中，连续流工具和技术的使用仍然很少。维多利亚大学的Leitch、Manners、McIndoe、Rosenberg和Wulff小组迫切需要连续流能力来解决各种问题，如化学反应开发、新生物活性分子的合成、理解复杂过程的化学反应性、构建化学合成自动化系统以及创建下一代聚合物和纳米颗粒材料。该提案寻求资助一个模块化的，定制的实验室流动化学系统，能够实现广泛的反应条件和规模。所提出的设备可以在标准实验室工作台的空间内操作，从几秒钟内进行反应的毫克材料到连续操作多天的公斤级合成。这一工具将使申请团体能够探索使用传统手段无法实现的全新研究途径。这些包括设计方法，使用多种同步技术连续分析化学反应，研究极端条件下的化学反应过程，安全地产生和处理高反应性和潜在危险的化学中间体，以生产新产品，并开发关键抗癌和抗感染药物的可扩展连续流合成，以应对加拿大未来的药物短缺。拟议的流动化学系统是最近成立的利奇集团的基础工具，并代表了UVic所有研究人员的独特培训机会。随着工业越来越依赖于精细化学品和药品的连续和自动化制造，我们的学生必须熟练使用流动化学技术和工具。这将使我们集团的研究人员成为开发和实施新的连续流技术的领导者。