Improving reproducibility of functional magnetic resonance imaging
提高功能磁共振成像的再现性
基本信息
- 批准号:RGPIN-2021-02393
- 负责人:
- 金额:$ 2.04万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2021
- 资助国家:加拿大
- 起止时间:2021-01-01 至 2022-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Both scientists and the general public are starting to recognize the "replication crisis" - that is, scientists do not always get the same results when they repeat the experiments of other scientists. Unfortunately, this seems to be the case more often than not in psychology, with one study finding that 61% of psychology studies cannot be replicated [1]. Recent headlines such as "Psychology's replication crisis is running out of excuses" [2] contribute to public mistrust of science. This can have devastating consequences for society, perhaps now more than ever. In the face of those who deny the safety and efficacy of vaccines, or the impact of human activities on climate change, we have a responsibility to always put science's best foot forward. How can we overcome the replication crisis and restore public confidence in the scientific method? My proposed research will contribute to this goal, by examining and improving reproducibility in a specific area of neuroscience, functional magnetic resonance imaging (fMRI). By allowing us to peer into the workings of the human brain without opening the skull, fMRI has revolutionized neuroscience research. This approach has captured the public's attention by providing visually impressive maps that pinpoint the precise location in the brain where certain functions (e.g., retrieving memories) take place. This striking localization power has allowed unprecedented investigations of functional neuroanatomy, that is, linking brain functions to different brain regions. However, like other fields of psychology, the results from fMRI studies cannot always be replicated. My work will investigate the different factors that contribute to fMRI reproducibility. I will attempt to replicate existing fMRI studies to better determine the extent of the reproducibility crisis in fMRI research specifically. I will also develop, distribute, and promote new tools for analyzing fMRI data that will improve reproducibility and allow more meaningful comparisons to be made across fMRI studies. Finally, I will perform experiments that test whether controlling for differences among individuals in behaviour or brain physiology can help improve fMRI reproducibility. Collectively, the outcomes of this work will be a major advance for fMRI. Currently, fMRI is not commonly used in clinical applications, in part because of reproducibility concerns. By improving fMRI reproducibility, we may eventually be able to harness fMRI's exquisite localization of brain function to better diagnosis and track progression of brain diseases, ultimately improving patient care. References [1] Open Science Collaboration. Estimating the reproducibility of psychological science. Science 349, aac4716 (2015). [2] Yong, E. Psychology's Replication Crisis Is Running Out of Excuses. The Atlantic https://www.theatlantic.com/science/archive/2018/11/psychologys-replication-crisis-real/576223/ (2018).
科学家和公众都开始认识到“重复危机”——也就是说,科学家在重复其他科学家的实验时并不总是得到相同的结果。不幸的是,这似乎在心理学中更常见,一项研究发现,61%的心理学研究无法被完全复制。最近的头条新闻,如“心理学的复制危机正在耗尽借口”,助长了公众对科学的不信任。这可能对社会造成毁灭性的后果,也许现在比以往任何时候都严重。面对那些否认疫苗安全性和有效性,或否认人类活动对气候变化影响的人,我们有责任始终把科学的最好一面展现出来。我们如何克服重复危机,恢复公众对科学方法的信心?我提出的研究将有助于实现这一目标,通过检查和提高神经科学特定领域的可重复性,功能性磁共振成像(fMRI)。功能磁共振成像技术让我们无需打开颅骨就能窥视人类大脑的运作,它彻底改变了神经科学研究。这种方法通过提供视觉上令人印象深刻的地图来精确定位大脑中某些功能(例如,检索记忆)发生的精确位置,从而吸引了公众的注意。这种惊人的定位能力使得功能性神经解剖学的研究前所未有,也就是说,将大脑功能与不同的大脑区域联系起来。然而,像心理学的其他领域一样,功能磁共振成像研究的结果并不总是可以复制的。我的工作是研究影响fMRI重现性的不同因素。我将尝试重复现有的功能磁共振成像研究,以更好地确定功能磁共振成像研究中可重复性危机的程度。我还将开发、分发和推广用于分析fMRI数据的新工具,这些工具将提高可重复性,并允许在fMRI研究中进行更有意义的比较。最后,我将进行实验,测试控制个体之间的行为或大脑生理学差异是否有助于提高fMRI的再现性。总的来说,这项工作的结果将是功能磁共振成像的重大进步。目前,功能磁共振成像在临床应用中并不常用,部分原因是对可重复性的担忧。通过提高功能磁共振成像的可重复性,我们可能最终能够利用功能磁共振成像对大脑功能的精确定位来更好地诊断和跟踪脑部疾病的进展,最终改善患者的护理。参考文献[1]开放科学协作。估计心理科学的可重复性。科学通报,36(2)(2015)。心理学的复制危机已经找不到借口了。大西洋杂志https://www.theatlantic.com/science/archive/2018/11/psychologys-replication-crisis-real/576223/(2018)。
项目成果
期刊论文数量(0)
专著数量(0)
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专利数量(0)
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Mazerolle, Erin其他文献
Mazerolle, Erin的其他文献
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{{ truncateString('Mazerolle, Erin', 18)}}的其他基金
Improving reproducibility of functional magnetic resonance imaging
提高功能磁共振成像的再现性
- 批准号:
RGPIN-2021-02393 - 财政年份:2022
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Grants Program - Individual
Improving reproducibility of functional magnetic resonance imaging
提高功能磁共振成像的再现性
- 批准号:
DGECR-2021-00004 - 财政年份:2021
- 资助金额:
$ 2.04万 - 项目类别:
Discovery Launch Supplement
Beyond the Activation Map: Calibrated Functional Magnetic Resonance Imaging in Cognitive Neuroscience
超越激活图:认知神经科学中的校准功能磁共振成像
- 批准号:
454132-2014 - 财政年份:2015
- 资助金额:
$ 2.04万 - 项目类别:
Postdoctoral Fellowships
Beyond the Activation Map: Calibrated Functional Magnetic Resonance Imaging in Cognitive Neuroscience
超越激活图:认知神经科学中的校准功能磁共振成像
- 批准号:
454132-2014 - 财政年份:2014
- 资助金额:
$ 2.04万 - 项目类别:
Postdoctoral Fellowships
Beyond the Activation Map: Calibrated Functional Magnetic Resonance Imaging in Cognitive Neuroscience
超越激活图:认知神经科学中的校准功能磁共振成像
- 批准号:
454132-2014 - 财政年份:2013
- 资助金额:
$ 2.04万 - 项目类别:
Postdoctoral Fellowships
Investigating brain connectivity: the structure and function of interhemispheric transfer
研究大脑连接:半球间传输的结构和功能
- 批准号:
317139-2007 - 财政年份:2008
- 资助金额:
$ 2.04万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Investigating brain connectivity: the structure and function of interhemispheric transfer
研究大脑连接:半球间传输的结构和功能
- 批准号:
317139-2007 - 财政年份:2007
- 资助金额:
$ 2.04万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Understanding the Relationship Between Hemodynamic and Electrophysiological Measures of Brain Function
了解脑功能的血流动力学和电生理测量之间的关系
- 批准号:
317139-2005 - 财政年份:2006
- 资助金额:
$ 2.04万 - 项目类别:
Postgraduate Scholarships - Master's
Understanding the Relationship Between Hemodynamic and Electrophysiological Measures of Brain Function
了解脑功能的血流动力学和电生理测量之间的关系
- 批准号:
317139-2006 - 财政年份:2006
- 资助金额:
$ 2.04万 - 项目类别:
Postgraduate Scholarships - Master's
Understanding the Relationship Between Hemodynamic and Electrophysiological Measures of Brain Function
了解脑功能的血流动力学和电生理测量之间的关系
- 批准号:
317139-2005 - 财政年份:2005
- 资助金额:
$ 2.04万 - 项目类别:
Postgraduate Scholarships - Master's
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