Regulation of terpenoid metabolism in lavender

薰衣草中萜类化合物代谢的调节

• 批准号: RGPIN-2021-02899
• 负责人: Mahmoud, Soheil
• 金额: $ 2.4万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=742271
• 关键词: Regulation; terpenoid; metabolism; lavender

This research will improve our understanding of the metabolism of the isoprenoids (or terpenoids), which encompass over 40,000 biochemical compounds in plants. Isoprenoids play crucial roles in the growth, development and ecology of plants. They are also industrially very significant and impact human lives in many ways, including as key constituents of functional foods, cosmetics, hygiene products, medicines, and biofuels, among others. Given the physiological roles and industrial importance of the terpenoids, there is considerable interest in understanding the molecular, biochemical and cellular mechanisms that control production of these metabolites in plants. The proposed studies primarily focus on the metabolism of terpenoids in lavender, a valuable crop plant, as a model system. Lavender produces large quantities of a commercially important monoterpene-rich essential oil (EO) in floral glandular trichomes, or oil glands, and is an excellent model for investigating regulation of isoprenoid production and storage in plants. Specific objectives are to: i) study the structural and regulatory genes involved in biosynthesis and secretion of EO constituents. ii) Investigate the partitioning of carbon flux into various terpenoid sub-classes. iii) Explore the molecular basis of the initiation and development of flowers, the specific sites for the production of commercially marketed lavender EO. This research generates knowledge in an important and currently very active area of plant science. The findings, which can be extrapolated to other plants, provide several avenues for improving EO yield and quality, and other important agronomic traits such as resistance to disease, through plant breeding and biotechnology. There is also excellent potential for development of technologies for enhancing the production of industrially important phytochemicals in plants, and in microbial and/or cell-free systems. Further, the research facilitates collaboration among university, government and industrial researchers and creates opportunities for training and employment of undergraduate and graduate students, and postdoctoral fellows. Additionally, the research benefits several industry sectors including nurseries, farmers, and businesses that rely on medicinal and industrial plants.

这项研究将提高我们对类异戊二烯（或萜类化合物）代谢的理解，其中包括植物中超过40，000种生化化合物。类异戊二烯在植物的生长、发育和生态中起着重要作用。它们在工业上也非常重要，并以多种方式影响人类生活，包括作为功能性食品、化妆品、卫生用品、药品和生物燃料等的关键成分。鉴于萜类化合物的生理作用和工业重要性，人们对理解控制植物中这些代谢物产生的分子、生化和细胞机制有相当大的兴趣。拟开展的研究主要集中在熏衣草，一种有价值的作物，作为模式系统的萜类化合物的代谢。熏衣草在花的腺毛或油腺中产生大量商业上重要的富含单萜类化合物的精油（EO），并且是研究植物中类异戊二烯产生和储存的调节的极好模型。具体目标是：i）研究参与EO组分生物合成和分泌的结构和调控基因。ii）研究碳通量到各种萜类化合物亚类的分配。iii）探索花的发生和发育的分子基础，以及商业销售熏衣草EO生产的具体位点。这项研究在植物科学的一个重要和目前非常活跃的领域产生知识。这些发现可以推广到其他植物，为通过植物育种和生物技术提高EO产量和质量以及其他重要的农艺性状（如抗病性）提供了几种途径。还存在开发用于增强植物中以及微生物和/或无细胞系统中工业上重要的植物化学物质的生产的技术的极好潜力。此外，研究促进大学，政府和工业研究人员之间的合作，并为本科生和研究生以及博士后研究员的培训和就业创造机会。此外，这项研究还使多个行业受益，包括依赖药用和工业植物的苗圃、农民和企业。