Gel permeation chromatography unit for comprehensive polymer analysis

用于综合聚合物分析的凝胶渗透色谱装置

• 批准号: RTI-2022-00383
• 负责人: Maric, Milan
• 金额: $ 10.93万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2021
• 资助国家: 加拿大
• 起止时间: 2021-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=742946
• 关键词: Gel; permeation; chromatography; unit; comprehensive

Size exclusion chromatography (SEC), alternatively known as gel permeation chromatography (GPC), is universally used to determine the molecular weight distribution of polymeric materials. Knowledge of the molecular weight distribution is essential for relating it to key properties such as viscosity (and in turn processing conditions) and tensile and impact strength, which dictate final use performance. GPC is also a powerful technique for elucidating polymerization mechanisms and with the appropriate detection unit, can supply essential structural information such as coil conformation in solution, degree of branching and tagging of functional groups. All of these features are vital for designing polymers for novel biological delivery systems, next-generation sealants and coatings and materials for composites and microelectronics. For example, all of the projects I am pursuing solely or in collaboration with my co-applicants requires the complete suite of detection capability offered by the GPC unit. These range from non-isocyanate poly(urethanes) without toxic feedstock, self-healing, low viscosity and low volatility aerospace coatings; green plasticizers with improved defect removing features in calendared films, bio-based composites and novel biodegradable polymeric gas hydrate inhibitors/promoters. Consequently, the GPC units must have multiple detectors such as refractive index (to measure concentration and derive the molecular weight distribution relative to polymeric standards) and intrinsic viscosity to reveal branching and solution properties of the polymer. Further, the unique set up of the unit requested allows rapid elution on the order of a few minutes, compared to the nearly one hour of our existing GPC, allowing nearly real-time feedback on the polymerization being studied.  The multiple solvent switching enabled also permits gradient chromatography and rapid changeover for different samples with differing solubilities, without having to change columns.  The configurations requested in this proposal meets the current analytical needs but more importantly, allow my students and collaborators to envision novel future capabilities of GPC to analyze the unique polymers and properties we are building into our materials.

粒径排除色谱法（SEC），也称为凝胶渗透色谱法（GPC），被广泛用于测定高分子材料的分子量分布。分子量分布的知识对于将其与粘度（以及加工条件）、拉伸和冲击强度等关键性能联系起来至关重要，这些性能决定了最终的使用性能。GPC也是一种阐明聚合机制的有力技术，通过适当的检测单元，可以提供基本的结构信息，如溶液中的线圈构象，分支程度和官能团的标记。所有这些特性对于设计用于新型生物输送系统的聚合物、下一代密封剂和涂层以及复合材料和微电子材料至关重要。例如，我单独或与我的共同申请人合作进行的所有项目都需要GPC单位提供的全套检测能力。这些范围从无有毒原料的非异氰酸酯聚氨酯，自修复，低粘度和低挥发性航空航天涂料；在压延膜、生物基复合材料和新型可生物降解聚合物气体水合物抑制剂/促进剂中具有改进缺陷去除功能的绿色增塑剂。因此，GPC单元必须具有多个检测器，例如折射率（用于测量浓度并推导相对于聚合物标准的分子量分布）和特性粘度，以显示聚合物的分支和溶液性质。此外，与我们现有的近一个小时的GPC相比，所要求的单元的独特设置允许在几分钟内快速洗脱，允许对所研究的聚合进行几乎实时的反馈。多种溶剂切换启用也允许梯度色谱和快速切换不同的样品具有不同的溶解度，而不必改变柱。本提案中要求的配置满足当前的分析需求，但更重要的是，允许我的学生和合作者设想GPC未来的新功能，以分析我们正在构建的材料中的独特聚合物和特性。