Novel bioinspired plasmonic nanocomposites platform for global health and global development applications

用于全球健康和全球发展应用的新型仿生等离子体纳米复合材料平台

• 批准号: RGPIN-2018-05675
• 负责人: WachsmannHogiu, Sebastian
• 金额: $ 4.81万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=744460
• 关键词: Novel; bioinspired; plasmonic; nanocomposites; platform

The goal of this proposal is to establish a research program in novel inexpensive nanobiocomposite materials that can be used in applications of global significance and address problems of global concern. Nanocomposite materials offer unique electrical, optical, thermal, and mechanical properties due to their exceptionally high surface-to-volume ratio. They have already found numerous technological applications and will likely transform our lives in the future. We propose to develop unique nanobiocomposites with unique and tunable properties that will find a wide range of applications. The fabrication of these structures is easily scalable and will yield inexpensive materials. The specific directions are to: (i) develop and characterize novel plasmonic, nanobiocomposite structures, (ii) evaluate the capillary flow of fluid through these structures for use in lateral flow assays, and (iii) explore potential applications to global health problems, and (iv) explore their potential applications in global development problems. These nanocomposites are inexpensive and flexible constructs made out of diatomic frustules (or diatomite), graphene, and plasmonic particles, and are fabricated in a variety of ways to fulfill the specific needs in the areas of molecular detection for diagnosis, particle separation for characterization, antibacterial applications, and improved hydrogen production towards clean energy. Specific aims1. Fabrication and characterization of inexpensive and flexible plasmonic nanocomposite structures on tape. Several fabrication methods and deposition of nanocomposites on a tape will be explored and optimized for applications targeting molecular detection. In this aim we will also perform preliminary measurements of these nanocomposites via SERS and evaluate their analytical capabilities on specific target molecules of interest ranging from small molecules such as toxins to proteins and DNA. COMSOL simulations of the electrical properties will also be performed. 2. Evaluate the flow of fluid through the nanocomposite and use it in lateral flow applications such as for the separation of molecular components for their detection and characterization. These constructs will be compared with more traditional lateral flow assays based on paper for sensitivity and multiplexing capability. 3. Fabricate and evaluate the use of these nanocomposites for health applications via detection and characterization of biomarkers of disease such as tuberculosis markers and extracellular vesicles. 4. Fabricate and use plasmonic nanocomposites targeted for several global development applications such as water purification, antimicrobial applications, and clean energy.

该提案的目的是在新颖的廉价纳米复合材料材料中建立一个研究计划，该计划可用于全球意义的应用并解决全球关注的问题。纳米复合材料由于其出色的表面体积比提供了独特的电气，光学，热和机械性能。他们已经找到了许多技术应用，并且可能会改变我们未来的生活。我们建议开发具有独特且可调属性的独特纳米复合材料，这些特性将发现广泛的应用。这些结构的制造很容易扩展，并且会产生廉价的材料。具体方向是：（i）开发和表征新型的等离子纳米生物复合材料结构，（ii）评估流体通过这些结构的毛细血管流以横向流量测定的使用，（iii）探索在全球健康问题上的潜在应用，以及（iv）探索其在全球发展问题中的潜在应用。这些纳米复合材料是廉价且灵活的构建体，该构建体是由双原子膜（或硅藻石），石墨烯和等离子颗粒制成的，并以多种方式制造，以满足分子检测领域的特定需求，用于诊断，粒子分离，用于特征化，抗细菌应用和改善水力生产和清洁能量。具体目标1。胶带上廉价且柔性的等离子纳米复合结构的制造和表征。将探索并优化纳米复合材料在胶带上的几种制造方法和沉积，以针对针对分子检测的应用进行优化。在此目的中，我们还将通过SERS对这些纳米复合材料进行初步测量，并评估其分析能力对特定目标分子的分析能力，从毒素等小分子到蛋白质和DNA。还将进行电气性能的comsol模拟。 2。评估流体通过纳米复合材料的流动，并将其用于横向流动应用中，例如将分子成分分离以进行检测和表征。这些结构将与基于纸张的更传统的横向流程分析进行比较，以提高灵敏度和多重能力。 3。通过检测和表征疾病的生物标志物（例如结核病标志物和细胞外囊泡）来制造和评估这些纳米复合材料在健康应用中的使用。 4。制造和使用针对几种全球开发应用的等离子纳米复合材料，例如水纯化，抗菌应用和清洁能量。