Development of antimicrobial coatings with transparent, universal, and UV-crosslinkable polymers

开发具有透明、通用和可紫外线交联聚合物的抗菌涂层

• 批准号: 571019-2021
• 负责人: Choi, HyoJickHJ
• 金额: $ 3.64万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=746810
• 关键词: Development; antimicrobial; coatings; transparent; universal

Contamination of solid surfaces represents a major route of infection and transmission of infectious air-borne, food-borne, and hospital-borne diseases. Currently, alcohol-based sanitizer, UV radiation, and disinfectant methods are widely used in many contaminated surfaces of medical masks/respirators, medical equipment and supplies, touchscreens, and food/pharmaceutical manufacturing facilities against harmful contaminants. While effective in deactivating biological contaminants on the surface, it is impossible to prevent unwanted contamination of the surface from the repeated direct contacts with the contaminated hands. Furthermore, the bacteria/virus can survive anywhere from a few hours to several days, raising an intrinsic concern of cross-infection and contact transmission. Therefore, development of a simple, but efficient antiseptic method for contaminated metal/plastic/glass surfaces has been considered as a key intervention technology in preventing spread of infectious diseases by contact with contaminated devices. In this research, we propose the development of a first-of-its-kind, self-sanitizing antimicrobial polymer coating that can be spray-coated on any type of substrate and is programmed to exhibit antimicrobial properties without the use of any harmful chemicals. Our approach has significant advantages as it eliminates concerns with regulatory restrictions regarding the safety and amount of biological/chemical agents used, development of bacterial resistance, and antimicrobial efficacy. Moreover, our technology can be easily translated to any type of surfaces in the form of metals, plastics, and glasses. We believe that this technology will make a significant contribution to rapid disinfection demand of industry, also to the general infection control strategy in Alberta and Canada.

固体表面的污染是空气传播、食物传播和医院传播的传染性疾病的主要感染和传播途径。目前，基于酒精的消毒剂、紫外线辐射和消毒方法被广泛用于医用口罩/消毒器、医疗设备和用品、触摸屏和食品/药品制造设施的许多污染表面，以防止有害污染物。虽然有效地使表面上的生物污染物失活，但不可能防止与受污染的手重复直接接触而对表面造成不希望的污染。此外，细菌/病毒可在任何地方存活数小时至数天，引起了交叉感染和接触传播的内在担忧。因此，开发一种简单但有效的金属/塑料/玻璃污染表面的消毒方法被认为是预防接触污染器械传播传染病的关键干预技术。在这项研究中，我们提出开发一种首创的自消毒抗菌聚合物涂层，该涂层可以喷涂在任何类型的基材上，并在不使用任何有害化学物质的情况下表现出抗菌性能。我们的方法具有显著的优势，因为它消除了对所用生物/化学制剂的安全性和数量、细菌耐药性的发展和抗菌功效的监管限制的担忧。此外，我们的技术可以很容易地转化为金属，塑料和玻璃形式的任何类型的表面。我们相信，这项技术将作出重大贡献，快速消毒的工业需求，也一般感染控制策略在阿尔伯塔和加拿大。