Development of total consumption systems for inductively coupled plasma mass spectrometry in single particle and single cell modes

单颗粒和单细胞模式电感耦合等离子体质谱总消耗系统的开发

• 批准号: 578516-2022
• 负责人: Beauchemin, DianeD
• 金额: $ 2.19万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=747300
• 关键词: Development; total; consumption; systems; inductively

Metal nanoparticles are increasingly used in cosmetics, food packaging, textiles, toothpaste, and other ubiquitous products. These nanoparticles may end up in the potable water of rural and indigenous communities without water treatment plants, putting these populations at risk. The impact of these nanoparticles on our environment, our food, and our health is largely unknown because measuring nanoparticles in environmental and biological systems is very difficult. Similarly, measuring the uptake of metal-containing drugs by cells to develop smart therapeutics targeting tumors is also difficult because it requires analysis of numerous individual cells to assess the selectivity of the drug uptake by diseased cells versus healthy cells. This partnership aims to develop sample introduction systems (one for the analysis of nanoparticles, one for the analysis of cells) allowing the quick analysis of every nanoparticle or cell in each sample, which is not currently possible, to provide a complete picture. The systems to be developed are expected to facilitate the analysis of real samples, such as natural waters and other environmental samples by reducing or eliminating the sample pretreatment that is currently required with standard sample introduction systems, thereby increasing the number of samples that can be analyzed daily. The system that will be optimized for the analysis of cells will be used to assess the efficiency and selectivity of new drugs being designed by collaborators. Such analysis will allow drug dosage to be adjusted so that cancerous cells are preferentially targeted. It would in turn allow the advancement of copper- and nickel-containing targeted therapeutics to treat cancer and neurological disorders. A switch from platinum (currently used in anti-cancer drugs) to copper or nickel in therapeutic candidates would greatly benefit patients' access to more affordable (hence equitable) and safer medication. The intention is to patent the resulting systems and allow Burgener Research, a Canadian manufacturer of sample introduction systems, to sell them. Canada would then become a world leader in the measurement of nanoparticles and cells.

金属纳米颗粒越来越多地用于化妆品，食品包装，纺织品，牙膏和其他普遍存在的产品中。 这些纳米颗粒可能最终在没有水处理厂的农村和土著社区的饮用水中，使这些人口处于危险之中。这些纳米颗粒对我们的环境，食物和健康的影响在很大程度上是未知的，因为在环境和生物系统中测量纳米颗粒非常困难。同样，通过细胞测量含金属的药物来开发靶向肿瘤的智能治疗剂的摄取也很困难，因为它需要对许多单个细胞的分析来评估患病细胞与健康细胞对药物摄取的选择性。 该合作伙伴关系旨在开发样品引入系统（一种用于分析纳米颗粒，一种用于分析细胞的分析），允许对每个样品中的每个纳米颗粒或细胞进行快速分析，目前无法提供完整的图片。预计要开发的系统将通过减少或消除标准样本简介系统当前所需的样品预处理，从而促进真实样品的分析，例如天然水和其他环境样品，从而增加每天可以分析的样品数量。 将对细胞分析进行优化的系统将用于评估合作者设计的新药的效率和选择性。 这种分析将使药物剂量进行调整，以便将癌细胞优先靶向。这反过来允许含有铜和镍靶向疗法的癌症和神经系统疾病的发展。 从白金（目前用于抗癌药物）转换为治疗候选者的铜或镍的转换将极大地使患者获得更多负担得起的（因此公平）和更安全的药物。目的是为了获得最终的系统专利，并允许Burgener Research（样本简介系统的加拿大制造商）出售它们。然后，加拿大将成为测量纳米颗粒和细胞的世界领导者。