SusChEM: New Chemistry of Carbene-Boranes

SusChEM：卡宾硼烷的新化学

• 批准号: 1265652
• 负责人: Dennis Curran
• 金额: $ 55.9万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265652&HistoricalAwards=false
• 关键词: SusChEM; New; Chemistry; Carbene; Boranes

In this project funded by the Chemical Synthesis Program of the Chemistry Division, Professor Dennis P. Curran of the Department of Chemistry at University of Pittsburgh will explore objectives in small molecule synthesis, polymer synthesis, and main group chemistry. Mechanistic experiments will be conducted to better understand newly discovered boryl radical homolytic substitution reactions with disulfides. The results will be used to develop new conditions for polarity reverse catalysis (PRC) reductions with NHC-boranes and to develop NHC-boranes as coinitiators for Type I and Type II radical photopolymerizations. Reactions of carbon-centered radicals with boron substituents will be studied and the products will be used for new kinds of cross coupling reactions. NHC-boranes will be developed as safe and practical reagents for common types of preparative hydride reductions. New methods for hydroboration based on borenium catalysts [NHC-BH2]+ will be developed. These could supplant transition-metal catalyzed reactions.The concepts and methods of this work deepen and broaden the disciplines of small molecule and polymer synthesis and help in the quest to provide the molecules, materials, and technologies that other disciplines that rely on to progress. There is a broad focus on sustainable chemistry with the common second row element boron (readily available, not toxic, easily reused) replacing rare, expensive or toxic elements. There is a strong coupling of advancing the frontiers of science with teaching, training and learning of the diverse group of undergraduate students and graduate students who do the day-to-day research work. They move into the workplace to become the human capital that drives progress in many areas that are vital to the health of our citizenry and the economy of our nation. The project also regularly uses technology like videoconferences to manage intercontinental collaborations. These collaborations expand the direct teaching/training impact of the proposal beyond Pittsburgh to Lyon and Mulhouse in France.

在这个由化学系化学合成计划资助的项目中，匹兹堡大学化学系的Dennis P. Curran教授将探索小分子合成，聚合物合成和主族化学的目标。 机理实验将进行更好地了解新发现的硼自由基均裂取代反应与二硫化物。 结果将被用来开发新的条件极性反转催化（PRC）减少与NHC-硼烷和开发NHC-硼烷作为共引发剂的I型和II型自由基光聚合。将研究碳中心自由基与硼取代基的反应，产物将用于新型交叉偶联反应。NHC-硼烷将被开发为用于制备氢化物还原的常见类型的安全和实用的试剂。 将开发基于Borenium催化剂[NHC-BH 2]+的硼氢化新方法。 这些可以取代过渡金属催化的反应。这项工作的概念和方法深化和拓宽了小分子和聚合物合成的学科，并有助于寻求提供其他学科所依赖的分子，材料和技术。 人们广泛关注可持续化学，用常见的第二行元素硼（容易获得，无毒，易于重复使用）取代稀有，昂贵或有毒的元素。 推进科学前沿与从事日常研究工作的本科生和研究生的教学，培训和学习有很强的耦合。 他们进入工作场所，成为推动许多领域进步的人力资本，这些领域对我们公民的健康和我们国家的经济至关重要。 该项目还经常使用视频会议等技术来管理洲际合作。 这些合作扩大了该建议的直接教学/培训影响，从匹兹堡到法国的里昂和穆尔豪斯。