Dynamic and degradable covalent chemistries to develop advanced polymeric materials

用于开发先进聚合物材料的动态和可降解共价化学

• 批准号: RGPIN-2021-03473
• 负责人: Oh, JungKwon
• 金额: $ 3.5万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748476
• 关键词: Dynamic; degradable; covalent; chemistries; develop

The research in my group, which falls in the field of polymer chemistry and materials, enables the design and processing of macromolecular nanoscale materials (named polymer-based nanomaterials) to address important problems in the crossroads of biology and materials science. The new research program proposed here aims for fundamental and applied studies of degradable and dynamic covalent chemistries to tailor important properties of advanced functional materials at nano- and microscales. Such smart chemistries involve the incorporation of either cleavable or dynamic (or reversible) linkages into the design of multifunctional copolymers and their materials. When needed, they undergo degradable disassembly or reversible dissociation/association in response to external stimuli. Various strategies will be developed to synthesize novel copolymers with various architectures and functionalities, which will be designed as effective building blocks in the construction of delivery nanoassemblies, polymer-nanoadditive hybrids, and self-healable network films. Our new research program is outlined with two research streams with several projects. In Stream 1, with our focus on degradation chemistries, we will explore the synthesis and disassembly of nanomaterials, degradable in the endogenous environment found in biological systems. We will study dual location degradable drug delivery mechanism and new cytosol-mediated gene release mechanism. In stream 2, with our emphasis on dynamic chemistries, we will develop new strategies to study self-healing mechanisms of hindered urea chemistry as well as design principles to develop novel energy harvesting materials and self-healable heterogeneous nanostructured networks. Our interdisciplinary research will provide HQP training in chemistry, biology, and engineering.

我小组的研究属于聚合物化学和材料领域，使大分子分子纳米级材料（命名为基于聚合物的纳米材料）的设计和处理能够解决生物学和材料科学十字路口的重要问题。这里提出的新研究计划的目的是针对可降解和动态共价化学物质的基本和应用研究，以量身定制纳米和显微镜的高级功能材料的重要特性。这种智能化学涉及将可切合或动态（或可逆的）链接纳入多功能共聚物及其材料的设计。在需要时，它们会响应外部刺激而经历可降解的分解或可逆解离/关联。将制定各种策略，以将新型共聚物与各种架构和功能合成，这些共聚物将被设计为在交付纳米组件，聚合物 - 纳米辅助式混合动力车和可自我关闭的网络膜的构建中的有效构件。我们的新研究计划概述了两个研究流，并有多个项目。在流1中，我们将重点放在降解化学上，我们将探索纳米材料的合成和拆卸，在生物系统中发现的内源性环境中可降解。我们将研究双重位置降解药物输送机制和新的细胞质介导的基因释放机制。在水流2中，我们将重点放在动态化学上，我们将开发新的策略来研究阻碍尿素化学的自我修复机制，以及设计原理，以开发新颖的能量收集材料和可自我修复的异质纳米结构网络。我们的跨学科研究将提供化学，生物学和工程学的HQP培训。