Dynamic and degradable covalent chemistries to develop advanced polymeric materials

用于开发先进聚合物材料的动态和可降解共价化学

• 批准号: RGPIN-2021-03473
• 负责人: Oh, JungKwon
• 金额: $ 3.5万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748476
• 关键词: Dynamic; degradable; covalent; chemistries; develop

The research in my group, which falls in the field of polymer chemistry and materials, enables the design and processing of macromolecular nanoscale materials (named polymer-based nanomaterials) to address important problems in the crossroads of biology and materials science. The new research program proposed here aims for fundamental and applied studies of degradable and dynamic covalent chemistries to tailor important properties of advanced functional materials at nano- and microscales. Such smart chemistries involve the incorporation of either cleavable or dynamic (or reversible) linkages into the design of multifunctional copolymers and their materials. When needed, they undergo degradable disassembly or reversible dissociation/association in response to external stimuli. Various strategies will be developed to synthesize novel copolymers with various architectures and functionalities, which will be designed as effective building blocks in the construction of delivery nanoassemblies, polymer-nanoadditive hybrids, and self-healable network films. Our new research program is outlined with two research streams with several projects. In Stream 1, with our focus on degradation chemistries, we will explore the synthesis and disassembly of nanomaterials, degradable in the endogenous environment found in biological systems. We will study dual location degradable drug delivery mechanism and new cytosol-mediated gene release mechanism. In stream 2, with our emphasis on dynamic chemistries, we will develop new strategies to study self-healing mechanisms of hindered urea chemistry as well as design principles to develop novel energy harvesting materials and self-healable heterogeneous nanostructured networks. Our interdisciplinary research will provide HQP training in chemistry, biology, and engineering.

我课题组的研究属于高分子化学和材料领域，能够设计和加工高分子纳米材料（称为聚合物基纳米材料），以解决生物学和材料科学交叉口的重要问题。这里提出的新研究计划旨在对可降解和动态共价化学进行基础和应用研究，以定制纳米和微米尺度的先进功能材料的重要特性。这种智能化学涉及将可裂解或动态（或可逆）连接纳入多功能共聚物及其材料的设计中。当需要时，它们会根据外部刺激进行可降解的分解或可逆的解离/缔合。将开发各种策略来合成具有各种结构和功能的新型共聚物，这些共聚物将被设计为构建输送纳米组件、聚合物-纳米添加剂杂化物和自修复网络薄膜的有效构件。我们的新研究计划概述了两个研究方向和多个项目。在第一部分中，我们将重点关注降解化学，探索纳米材料的合成和分解，这些材料可在生物系统的内源环境中降解。我们将研究双定位可降解药物递送机制和新的胞质介导的基因释放机制。在第二部分中，我们将重点关注动态化学，我们将开发新策略来研究受阻尿素化学的自修复机制，以及开发新型能量收集材料和自修复异质纳米结构网络的设计原理。我们的跨学科研究将提供化学、生物学和工程学方面的 HQP 培训。