Explorating stimuli-responsive degradation: a versatile platform to develop multifunctional polymeric nanomaterials

探索刺激响应性降解：开发多功能聚合物纳米材料的多功能平台

• 批准号: RGPIN-2016-04989
• 负责人: Oh, JungKwon
• 金额: $ 2.19万
• 依托单位: Concordia University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2019
• 资助国家: 加拿大
• 起止时间: 2019-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=683461
• 关键词: Explorating; stimuli; responsive; degradation; versatile

The research in my laboratory enables the design and processing of macromolecular nanoscale materials (nanomaterials) to address important problems at the crossroads of biology and materials science. A stimuli-responsive degradation (SRD) platform involves the incorporation of dynamic covalent bonds (or cleavable linkages) into nanomaterials, which can be cleaved in response to external stimuli (acidic pH and light as well as reductive, oxidative, and enzymatic reactions), when required. SRD-exhibiting nanomaterials are designed to be degradable upon the cleavage of dynamic linkages, thus allow us to change physical property, control morphology, and importantly enhance drug release. ***My research program focuses on the exploration of the versatile SRD to develop a variety of advanced multifunctional nanomaterials as delivery nanocarriers, cellular imaging agents, and tissue scaffolds as well as fuel cell polymeric materials. These novel materials can interface with biological processes, and an understanding of their biological functions can offer enormous potential for cancer research, diagnosis and therapeutics. Furthermore, our development of high-value polymeric materials for energy-related applications will greatly contribute to global efforts in conserving fossil fuels as well as developing alternative energy sources. This research program outlined with four objectives will impact on our fundamental understanding and advancement of knowledge regarding how to design polymer-based nanomaterials for biological and nanoscience research.***

我的实验室的研究使大分子纳米级材料（纳米材料）的设计和处理能够解决生物学和材料科学十字路口的重要问题。刺激反应性降解（SRD）平台涉及将动态共价键（或可裂解的连锁）掺入纳米材料中，可以在需要时响应外部刺激（酸性pH和光以及还原，氧化和酶促反应），以响应外部刺激而裂解。 SRD探测的纳米材料设计为在动态连接的裂解上可降解，从而使我们能够更改物理性质，控制形态，并重要地增强了药物释放。 ***我的研究计划着重于对多功能SRD的探索，以开发各种高级多功能纳米材料，例如输送纳米载体，细胞成像剂和组织支架以及燃料电池聚合物材料。这些新颖的材料可以与生物学过程接触，对它们的生物学功能的理解可以为癌症研究，诊断和治疗剂提供巨大的潜力。此外，我们开发用于能源相关应用的高价值聚合物材料将极大地有助于全球保护化石燃料以及开发替代能源的努力。该研究计划概述了四个目标，将影响我们对如何设计基于聚合物的纳米材料的知识的基本理解和进步。*** ***