Development of a facile strategy to synthesize PLA-based reduction-responsive shell-sheddable nanoassemblies for drug delivery****
开发一种简单的策略来合成用于药物输送的基于 PLA 的还原响应可脱壳纳米组件****
基本信息
- 批准号:537993-2018
- 负责人:
- 金额:$ 1.82万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Engage Grants Program
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Current trend in polymer-based nanomedicine for cancer therapy mainly focuses on the development of block copolymer-based nanoassemblies with hydrophobic cores enabling the encapsulation of hydrophobic anticancer drugs. Recently, well-defined block copolymers consisting of hydrophobic polylactide (PLA) and hydrophilic poly(ethylene glycol) (PEG) blocks have been currently practiced in clinics. However, the conventional systems rely on diffusion-controlled mechanism, which is passive, uncontrolled, and slow for the release of encapsulated anticancer drugs. The research opportunity here is to explore reduction-responsive degradation platform for cancer therapy with enhanced/controlled drug release profile. ****In this proposed research, in collaboration with Advanced Polymeric Materials (APM) located in Montreal, we will explore a facile strategy to incorporate disulfide linkage into the design of conventionally-designed PLA-b-PEG block copolymers. The strategy will utilize a combination of click-type alkyne-azido cycloaddition reaction with ring opening polymerization to synthesize novel block copolymer having a reduction-responsive disulfide linkage (SS) at the junction of PLA and PEG blocks, thus PLA-SS-PEG block copolymers. Important parameters including block lengths and the number of alkyl groups adjacent to SS linkage will be varied to understand the structure-property relationship. Further, the synthesized copolymers will be evaluated for effective intracellular drug delivery. This collaborative project will offer APM a great opportunity to be competitive in markets over their competitors.
目前基于聚合物的纳米药物用于癌症治疗的发展趋势主要集中在以嵌段共聚物为基础的具有疏水核的纳米组装体的开发,从而使疏水性抗癌药物能够被包裹。最近,由疏水性聚乳酸(PLA)和亲水性聚乙二醇(PEG)嵌段组成的定义明确的嵌段共聚物目前已在临床上得到应用。然而,传统的系统依赖于扩散控制机制,这种机制是被动的、不受控制的、包囊抗癌药物释放缓慢的。这里的研究机会是探索具有增强/受控药物释放轮廓的癌症治疗的还原响应性降解平台。*在这项拟议的研究中,我们将与蒙特利尔的先进聚合物材料公司(APM)合作,探索一种简便的策略,将二硫键结合到传统设计的解放军-b-聚乙二醇嵌段共聚物的设计中。该策略将利用点击式的炔-叠氮环加成反应和开环聚合相结合的方法合成新型嵌段共聚物,该嵌段共聚物在聚乳酸和聚乙二醇嵌段的交界处具有还原响应性的二硫键(SS),从而得到聚乳酸-聚乙二醇单嵌段共聚物。重要的参数,包括链段长度和与SS键相邻的烷基数量将发生变化,以了解结构与性质的关系。此外,合成的共聚物将被评估为有效的细胞内药物输送。这一合作项目将为APM提供一个极好的机会,使其在市场上比竞争对手更具竞争力。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Oh, JungKwon其他文献
Oh, JungKwon的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Oh, JungKwon', 18)}}的其他基金
Dynamic and degradable covalent chemistries to develop advanced polymeric materials
用于开发先进聚合物材料的动态和可降解共价化学
- 批准号:
RGPIN-2021-03473 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Dynamic and degradable covalent chemistries to develop advanced polymeric materials
用于开发先进聚合物材料的动态和可降解共价化学
- 批准号:
RGPIN-2021-03473 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Explorating stimuli-responsive degradation: a versatile platform to develop multifunctional polymeric nanomaterials
探索刺激响应性降解:开发多功能聚合物纳米材料的多功能平台
- 批准号:
RGPIN-2016-04989 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Explorating stimuli-responsive degradation: a versatile platform to develop multifunctional polymeric nanomaterials
探索刺激响应性降解:开发多功能聚合物纳米材料的多功能平台
- 批准号:
RGPIN-2016-04989 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Acidic pH-responsive drug delivery
酸性pH响应性药物递送
- 批准号:
536701-2018 - 财政年份:2018
- 资助金额:
$ 1.82万 - 项目类别:
Connect Grants Level 1
Explorating stimuli-responsive degradation: a versatile platform to develop multifunctional polymeric nanomaterials
探索刺激响应性降解:开发多功能聚合物纳米材料的多功能平台
- 批准号:
RGPIN-2016-04989 - 财政年份:2018
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Development of robust self-healable heterogeneous crosslinked films
开发坚固的自修复异质交联薄膜
- 批准号:
522033-2017 - 财政年份:2017
- 资助金额:
$ 1.82万 - 项目类别:
Engage Grants Program
相似海外基金
Development of a rapid and facile platform for testing viral escape-resistance of therapeutic antibodies & vaccines & determining escape mutations
开发快速简便的平台来测试治疗性抗体的病毒逃逸抗性
- 批准号:
MR/X009521/1 - 财政年份:2023
- 资助金额:
$ 1.82万 - 项目类别:
Research Grant
Facile One-Pot Reductive Deoxygenations of Alcohols and Carboxylic Acids Using Sulfuryl Fluoride
使用硫酰氟轻松进行醇和羧酸的一锅还原脱氧
- 批准号:
546996-2020 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Development of a facile, robust, scalable, and versatile chemoenzymatic glycan-remodeling approach for site-specific antibody conjugation
开发一种简便、稳健、可扩展且多功能的化学酶聚糖重塑方法,用于位点特异性抗体缀合
- 批准号:
10615237 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Development of the three-component reaction for facile synthesis of unsymmetric bisphosphine ligands
轻松合成不对称双膦配体的三组分反应的发展
- 批准号:
22K14673 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Facile Access to Bulk Gallium and Boron Nitrides for Semiconductor Applications
轻松获得用于半导体应用的块状氮化镓和氮化硼
- 批准号:
575705-2022 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Master's
Development of a facile, robust, scalable, and versatile chemoenzymatic glycan-remodeling approach for site-specific antibody conjugation
开发一种简便、稳健、可扩展且多功能的化学酶聚糖重塑方法,用于位点特异性抗体缀合
- 批准号:
10484443 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
CAREER: Facile molecular computation and diagnostics via fast, robust, and reconfigurable DNA circuits
职业:通过快速、稳健且可重新配置的 DNA 电路进行简便的分子计算和诊断
- 批准号:
2143227 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Continuing Grant
CAREER: Heterobimetallic Complexes for Facile Hydrodenitrogenation Processes with Low Hydrogen Intake
事业:用于低氢摄入量的简易加氢脱氮过程的异双金属配合物
- 批准号:
2145588 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Standard Grant
Paper-based Breastmilk Collection System for Facile, In-Home Use
方便家庭使用的纸质母乳收集系统
- 批准号:
10641685 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:














{{item.name}}会员




