Replace an obsolete Zetasizer for nanoparticle, colloid and protein size & charge measurements

更换过时的 Zetasizer 纳米粒子、胶体和蛋白质尺寸

• 批准号: RTI-2023-00458
• 负责人: Siaj, Mohamed
• 金额: $ 10.56万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748713
• 关键词: Replace; obsolete; Zetasizer; nanoparticle; colloid

Inorganic, organic and bio-nanomaterials based research and development is a continuously evolving effort to control substances at the atomic and molecular level to achieve new and better materials and products. The miniaturization of components is necessary to achieve faster, higher-performance devices and functions and to reduce energy consumption. Inorganic, organic and  bio-nanomaterials have come to play a key role in a wide range of fields affecting our daily lives, including energy, electronics, medical, environmental protection, bioengineering industries, and the life sciences. They play a critical role in science and technological developments and can enhance a nation's economy. Deploying these technologies will require the application of knowledge, concepts, and tools from a variety of fields including those mentioned above. This relies on our understanding of the structure, morphology, activity and stability of bio, organic and inorganic materials for the targeted applications.    The aim of this proposal is to purchase a new generation Zetasizer Advance Series-Ultra (Red Label) as a highly versatile instrument allowing the measurement of size, molecular weight, concentration, and zeta potential of dispersed particles and molecules using Dynamic light scattering (DLS), Static Light-Scatering (SLS), Multi-angle Dynamic Light Scattering (MADLS) and Zeta potential measurement techniques. The simplicity and the accuracy of the Zetasizer Advance Series-Ultra method have made it a crucial analysis tool for measurement of size, molecular weight, concentration, and zeta potential of dispersed particles and molecules. The requested new generation Zetasizer Advance Series-Ultra equipment will offer a set of unprecedented capabilities in terms of sensitivity and accurate measurements regardless of analysis time, allowing measurements to be performed with precision.    The equipment will be directly used by at least 47 HQP, adding an important component to their training and increase their employability. It is needed urgently to replace two inoperative first-generation, obsolete machines located at UQAM and Concordia University (acquired over 25 years ago), which is critical to the research of all co-applicants and will raise their ability to build and strengthen their collaborations with academia and industry. It is required for research programs in areas of high socioeconomic importance to Canada, e.g., nanomaterials, bionanomaterials synthesis, energy conversion and storage, sensors, and vaccines. Considering the global importance of these areas, the acquisition of this equipment will enable our researchers to develop accurate bio, inorganic and organic functional nanomaterials and shed light on the relationship between the physical, chemical, and biological activities of these nanomaterials regarding particle size distribution, concentration, and molecular weight, helping propel Canadian research several cutting edge fields.

基于无机、有机和生物纳米材料的研究和开发是一项不断发展的努力，旨在在原子和分子水平上控制物质，以获得新的和更好的材料和产品。组件的小型化对于实现更快、更高性能的设备和功能以及降低能耗是必要的。无机、有机和生物纳米材料在影响我们日常生活的广泛领域中发挥着关键作用，包括能源、电子、医疗、环境保护、生物工程行业和生命科学。它们在科学和技术发展中发挥着关键作用，可以增强一个国家的经济。部署这些技术将需要应用包括上述领域在内的各个领域的知识、概念和工具。这依赖于我们对生物、有机和无机材料的结构、形态、活性和稳定性的理解。 本提案的目的是购买新一代Zetasizer Advance Series-Ultra（红标），这是一种高度通用的仪器，可以使用动态光散射（DLS）、静态光散射（SLS）、多角度动态光散射（MADLS）和Zeta电位测量技术测量分散颗粒和分子的尺寸、分子量、浓度和Zeta电位。Zetasizer Advance Series-Ultra方法的简单性和准确性使其成为测量分散颗粒和分子的尺寸、分子量、浓度和zeta电位的重要分析工具。所要求的新一代Zetasizer Advance Series-Ultra设备将在灵敏度和准确测量方面提供一系列前所未有的功能，而不受分析时间的限制，从而可以精确地进行测量。 这些设备将直接由至少47名HQP使用，为他们的培训增加了重要组成部分，并提高了他们的就业能力。迫切需要更换位于UQAM和Concordia大学（25年前收购）的两台第一代过时机器，这对所有共同申请人的研究至关重要，并将提高他们建立和加强与学术界和工业界合作的能力。它是需要在高社会经济重要性的加拿大，例如，纳米材料、生物纳米材料合成、能量转换和储存、传感器和疫苗。考虑到这些领域的全球重要性，该设备的收购将使我们的研究人员能够开发出准确的生物，无机和有机功能纳米材料，并阐明这些纳米材料的物理，化学和生物活性之间的关系，这些纳米材料的粒度分布，浓度和分子量，有助于推动加拿大研究的几个前沿领域。