MELIORATA : MEtaboLic engIneering fOR cAnnabinoids producTion in microAlgae

MELIORATA：微藻中大麻素生产的代谢工程

• 批准号: 570476-2021
• 负责人: DesgagnéPenix, IsabelI
• 金额: $ 36.38万
• 依托单位: Université du Québec à Trois-Rivières
• 依托单位国家: 加拿大
• 项目类别: Alliance Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=748741
• 关键词: MELIORATA; MEtaboLic; engIneering; cAnnabinoids; producTion

Challenge : Increasing and optimizing the production of plant-based metabolites utilizing genetically modified microalgae. Algae-C is Canadian biosynthetic company using microalgae to produce biomolecules of interest. It enableson-site production of algae for a wide variety of sectors (aquaculture, nutraceutical, cosmetic and biofuel). Todate, many fuels, pharmaceuticals and cosmetic products are extracted from plants. These valuable plantnatural products are often produced in low quantities in plants and extraction methods can be long andexpensive. Thus, there is much interest in metabolic engineering for developing microbial platforms to producespecific plant product of interest. Microalgae are well-known systems for plant biology and genetic engineeringand are interesting and suitable hosts for the reconstitution of complex plant pathways. Algae-C wishes tocontinue to translate metabolic engineering research into industrial processes. This project aims to optimizedmicroalgae platforms for the production of valuable cannabinoids. These ventures are motivated by consumerdemand for products that are environmentally friendly, less expensive, and possess properties similar orsuperior with those generated by plants.

挑战：利用转基因微藻增加和优化植物代谢物的生产。Algae-C是加拿大生物合成公司，使用微藻生产感兴趣的生物分子。它可以为各种行业（水产养殖、营养品、化妆品和生物燃料）现场生产藻类。今天，许多燃料、药品和化妆品都是从植物中提取的。这些有价值的植物天然产物通常在植物中产量很低，提取方法可能是长期和昂贵的。因此，人们对代谢工程产生了很大的兴趣，以开发微生物平台来生产感兴趣的特定植物产品。微藻是植物生物学和基因工程的重要研究对象，也是植物复杂代谢途径重组的理想宿主。Algae-C希望继续将代谢工程研究转化为工业过程。该项目旨在优化微藻平台，以生产有价值的大麻素。这些企业的动机是消费者对产品的需求，这些产品对环境友好，价格低廉，具有与植物产生的产品相似或更好的性能。