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Identification of Genetic Variants Influencing the Likelihood of Methotrexate-Induced Mucositis Development in Children Using Pathway Analysis

Identification of Genetic Variants Influencing the Likelihood of Methotrexate-Induced Mucositis Development in Children Using Pathway Analysis
使用通路分析鉴定影响儿童甲氨蝶呤诱发粘膜炎发生可能性的遗传变异
批准号：
485887
负责人：
Zhang XIAO YU
金额：
$1.27万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2022
资助国家：
加拿大
项目状态：
已结题
起止时间：
2022-12-01 至 2023-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=485887&lang=en
关键词：
Adverse Drug Reactions Surveillance Bioinformatics And Biotechnology Gene Set Enrichment Analysis Medical Genetics Methotrexate Mucositis Oncology Clinical Practice Pathobiological Pathways Pediatrics Pharmacogenomics

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Methotrexate, while an effective, widely used drug in childhood cancer, causes debilitating mucositis — a painful condition in various soft tissues, which often results in the inability to eat and subsequently, malnutrition. In severe cases, open sores le
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