Identification of Genetic Variants Influencing the Likelihood of Methotrexate-Induced Mucositis Development in Children Using Pathway Analysis

使用通路分析鉴定影响儿童甲氨蝶呤诱发粘膜炎发生可能性的遗传变异

• 批准号: 485887
• 负责人: Zhang XIAO YU
• 金额: $ 1.27万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-12-01 至 2023-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=485887&lang=en
• 关键词: Adverse Drug Reactions Surveillance; Bioinformatics And Biotechnology; Gene Set Enrichment Analysis; Medical Genetics; Methotrexate; Mucositis; Oncology Clinical Practice; Pathobiological Pathways; Pediatrics; Pharmacogenomics

Methotrexate, while an effective, widely used drug in childhood cancer, causes debilitating mucositis — a painful condition in various soft tissues, which often results in the inability to eat and subsequently, malnutrition. In severe cases, open sores le

甲氨蝶呤虽然是一种有效的、广泛用于儿童癌症的药物，但会引起使人衰弱的粘膜炎-一种在各种软组织中的疼痛状况，这往往导致无法进食，随后营养不良。在严重的情况下，