Bioinformatics and Biotechnology

生物信息学和生物技术

• 批准号: 8459555
• 负责人: CLAYTON W. NAEVE
• 金额: $ 15.6万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8459555
• 关键词: Algorithms; Archives; Bioinformatics; Biometry; Biotechnology; Brain; Brain Neoplasms; Childhood Brain Neoplasm; Custom; DNA; DNA Microarray Chip; DNA analysis; Data; Data Analyses; Databases; Development; Doctor of Philosophy; Faculty; Funding; Gene Expression Profiling; Group Meetings; High Performance Computing; Housing; Human Resources; Informatics; Institution; Instruction; Investigation; Laboratories; Laboratory Research; Linux; MicroRNAs; Microarray Analysis; Molecular Profiling; Mus; Neoplasms; Oligonucleotide Microarrays; Paper; Principal Investigator; Process; Productivity; RNA; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Role; Saint Jude Children' s Research Hospital; Sampling; Scientist; Seminal; Services; Spottings; Structure; System; Technology; Wages; Work; base; data management; data sharing; design; experience; human tissue; instrumentation; meetings; member; new technology; operation; programs; relational database; research study; skills; success

through the Custom Array laboratory. This second laboratory also supports the import and development of new array technologies e.g., micro-RNA arrays, that are of particular relevance to the current proposal. The Custom Array laboratory has been in operation for 7 years, and has processed over 5,500 samples to date. Core B is investing continually in state-of-the-art instrumentation: recent enhancements include a new spotted array printer (Qarray2) and several new Affymetrix fluidics workstations and scanners (in total 8 fluidics workstations and 3 high-resolution scanners each with autosamplers). Together, these laboratories have produced and assisted in the analysis of over 27,000 microarray profiles, thereby contributing critically to the research of this Program and other laboratories across SJCRH. Core B also includes substantial bioinformatics and biostatistics expertise that will provide support and computational hardware to the Program. These resources that are crucial for the completion of array based experiments include eight Ph.D.-level bioinformaticists (one of which is dedicated to this P01, Dr. Chunxu Qu) and 12 other highly skilled technical staff. Drs. Pounds and Zhao, who are faculty members in Biostatistics, also bring unique and extensive expertise in microarray data analysis. The high performance computing facility associated with Core B includes a 420-cpu Linux cluster, 150 Tb storage capacity, and a wealth of bioinformatics applications including LaserGene, Affymetrix LIMS system, Spotfire DecisionSite, R, and many other applications suitable for sequence and gene expression analysis. We seek partial support for one bioinformaticist dedicated to this Program (Dr. Chunxu Qu). RELEVANCE (See instructions): To provide molecular profiling and bioinformatics support for investigation of pediatric brain tumors PROJECT/

通过自定义阵列实验室。这第二个实验室还支持进口和发展 与当前提案特别相关的新的阵列技术，例如微型RNA阵列。这个 定制阵列实验室已经运行了7年，到目前为止已经处理了5500多个样品。 核心B不断投资于最先进的仪器设备：最近的增强包括一个新的 斑点阵列打印机(Qarray2)以及几个新的Affymetrix流体工作站和扫描仪(共8台 流体工作站和3台高分辨率扫描仪(每台扫描仪都配有自动取样器)。这些实验室加在一起， 制作并协助分析了27,000多个微阵列图谱，从而做出了重要贡献 这项计划的研究和上海华侨大学的其他实验室。核心B还包括大量 生物信息学和生物统计学专业知识，将为 程序。这些对完成基于阵列的实验至关重要的资源包括八个 博士级别的生物信息学家(其中一人致力于本P01，曲春旭博士)和其他12名高度 熟练的技术人员。生物统计学教员庞德和赵博士也带来了独特的 以及在微阵列数据分析方面的广泛专业知识。与之相关的高性能计算设施 核心B包括420个CPU的Linux集群、150 TB的存储容量和丰富的生物信息学 应用程序包括Lasergene、Affymetrix LIMS系统、Spotfire DecisionSite、R等 适用于序列和基因表达分析的应用。我们寻求对其中一个的部分支持 致力于这一计划的生物信息学家(屈春旭博士)。 相关性(请参阅说明)： 为儿童脑肿瘤的研究提供分子图谱和生物信息学支持 项目/