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Pre-clinical studies of a small-molecule to reverse neurodegenerative disease-causing mutations for its commercialization and application

Pre-clinical studies of a small-molecule to reverse neurodegenerative disease-causing mutations for its commercialization and application
逆转神经退行性疾病引起的突变的小分子的临床前研究及其商业化和应用
批准号：
490424
负责人：
Pearson Christopher E
金额：
$52.39万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
未结题
起止时间：
2023-09-01 至 2026-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=490424&lang=en
关键词：
Cag/Ctg Repeat Expansions Commercialization Huntington'S Disease Naphtyridine Azaquinolone (Na) Pre-Clinical Studies Repeat Instability Small Compound Spinocerebellar Ataxia (Scas) Transgenic Mice

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中文摘要
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英文摘要
Huntington's disease (HD) is caused by mutations in repeated DNAs. If one considers a gene as though it were a sentence such as THE CAT ATE THE FAT RAT, typical mutations would be spelling errors, like THE GAT ATE THE FAT RAT. This mutation would be the s
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FAN1, a DNA repair nuclease, as a modifier of disease-associated repeat instability.
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    462785
  • 项目类别：
    Operating Grants
  • 资助金额：
    $69.66万
  • 财政年份：
    2022
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    Pearson Christopher E
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    Hospital for Sick Children (Toronto)
DNA repair proteins as modifiers of CAG repeat instability in Huntington's disease
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    $70.22万
  • 财政年份：
    2020
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    Pearson Christopher E
  • 依托单位：
    Hospital for Sick Children (Toronto)
Somatic DNA mosaicism of the ADNP gene in cells, ADNP-mouse tissues and tissues of a post-mortem ADNP individual: An indication of how this may affect disease.
  • 批准号：
    387299
  • 项目类别：
    Operating Grants
  • 资助金额：
    $16.39万
  • 财政年份：
    2018
  • 负责人：
    Pearson Christopher E
  • 依托单位：
    Hospital for Sick Children (Toronto)
Canada Research Chair - Tier 1
  • 批准号：
    404349
  • 项目类别：
  • 资助金额：
    $101.99万
  • 财政年份：
    2018
  • 负责人：
    Pearson Christopher E
  • 依托单位：
    University of Toronto
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