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FAN1, a DNA repair nuclease, as a modifier of disease-associated repeat instability.

FAN1, a DNA repair nuclease, as a modifier of disease-associated repeat instability.
FAN1 是一种 DNA 修复核酸酶，作为疾病相关重复不稳定性的修饰剂。
批准号：
462785
负责人：
Pearson Christopher E
金额：
$69.66万
依托单位：
Hospital for Sick Children (Toronto)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2022
资助国家：
加拿大
项目状态：
未结题
起止时间：
2022-03-01 至 2027-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=462785&lang=en
关键词：
Cag/Ctg Repeat Expansions Dna Repair Fan1 Nuclease Fan1-Mlh1 Interaction Huntington'S Disease Mlh1 Complex Repeat Instability Spinocerebellar Ataxia (Scas) Transgenic Mice

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中文摘要
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英文摘要
Huntington's disease (HD) is caused by mutations in repeated DNAs. If one considers a gene as though it were a sentence such as THE CAT ATE THE FAT RAT, typical mutations would be spelling errors, like THE GAT ATE THE FAT RAT. This mutation would be the s
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