FAN1, a DNA repair nuclease, as a modifier of disease-associated repeat instability.

FAN1 是一种 DNA 修复核酸酶，作为疾病相关重复不稳定性的修饰剂。

• 批准号: 462785
• 负责人: Pearson Christopher E
• 金额: $ 69.66万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-03-01 至 2027-03-01
• 项目状态: 未结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=462785&lang=en
• 关键词: Cag/Ctg Repeat Expansions; Dna Repair; Fan1 Nuclease; Fan1-Mlh1 Interaction; Huntington'S Disease; Mlh1 Complex; Repeat Instability; Spinocerebellar Ataxia (Scas); Transgenic Mice

Huntington's disease (HD) is caused by mutations in repeated DNAs. If one considers a gene as though it were a sentence such as THE CAT ATE THE FAT RAT, typical mutations would be spelling errors, like THE GAT ATE THE FAT RAT. This mutation would be the s

亨廷顿病（HD）是由重复DNA突变引起的。如果我们把基因看作是一个句子，比如“猫吃了胖老鼠”，那么典型的突变就是拼写错误，比如“门吃了胖老鼠”。这种突变将是