Understanding the molecular mechanism of force generation in the bacterial flagellar motor

了解细菌鞭毛运动中力产生的分子机制

• 批准号: DP1094619
• 负责人: A/Prof Anna Roujeinikova
• 金额: $ 33.73万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2015-01-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1094619
• 关键词: Understanding; molecular; mechanism; force; generation

The proposed research will advance the knowledge about how the bacterial flagellar motor works, enabling scientists to learn more about nature's blueprint of a nanoscale engine. It will address the fundamental question of how bacterial cells convert electrochemical energy into mechanical energy of rotation. At present, the smallest artificial electric motor is still on a micro-, rather than nanoscale. Nanotechnology would therefore benefit from this work by basing their designs on the principles behind the mechanism of the bacterial motor. This research is also of interest for veterinary science, as motility by flagellar motor is a key virulence factor of common animal pathogens associated with, for example, listeriosis and gastroenteritis.

这项拟议中的研究将推进关于细菌鞭毛马达如何工作的知识，使科学家能够更多地了解自然界的纳米引擎蓝图。它将解决细菌细胞如何将电化学能转化为旋转机械能的基本问题。目前，最小的人造电动机还停留在微米级，而不是纳米级。因此，纳米技术将从这项工作中受益，因为它们的设计基于细菌马达机制背后的原理。这项研究也是兽医学的兴趣，因为鞭毛运动是常见动物病原体的关键毒力因子，例如，与绦虫病和胃肠炎有关。