Laws of attraction and repulsion: a novel family of bacterial chemo-sensors

吸引力和排斥定律：新型细菌化学传感器家族

• 批准号: DP180101807
• 负责人: A/Prof Anna Roujeinikova
• 金额: $ 30.06万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP180101807
• 关键词: Laws; attraction; repulsion; novel; family

This project aims to reveal the structural basis for the abilities of a newly characterised, widespread family of chemotaxis receptors to sense and distinguish between attractants and repellents. Many bacteria are motile. Controlling the movement of bacterial populations requires understanding of their chemosensory mechanisms. It is anticipated that this work will generate significant new knowledge in the field of signalling biology that will drive the discovery of novel chemo-effectors and the redesign of receptor specificity. Innovative use of this knowledge could be the development of new classes of repellents that are not toxic. These could be used as a means to prevent infections caused by bacterial build-up on implanted medical devices.

这个项目旨在揭示一个新的、广泛的趋化受体家族感知和区分引诱剂和驱避剂的能力的结构基础。许多细菌都是能动的。控制细菌种群的移动需要了解它们的化学感觉机制。预计这项工作将在信号生物学领域产生重要的新知识，推动新的化学效应的发现和受体特异性的重新设计。这一知识的创新应用可能是开发无毒的新型驱虫剂。这些可以作为一种手段来防止植入的医疗设备上的细菌积聚引起的感染。