攻击行为表型差异的原因与机制研究取得了很大进展，但由于攻击行为的异质性、多基因决定性、外显不全性等阻碍了差异的原因与机制的深入研究。本研究拟通过总结国内外攻击行为相关疾病GWAS研究得出的候选基因的基础上，对主动性和反应性攻击各100例青少年进行目标区域测序后，选取两类攻击青少年各400例，采用1:1病例对照研究进行群体验证，寻找其易感基因的差异，并从表观遗传学甲基化水平探讨攻击行为表型差异性的原因与机制，分析基因---基因、基因—环境、基因---行为的交互作用，同时建立风险预测模型以便早期诊断和预防。

Improvements have been made in the researches on the causes and mechanisms of phenotypic diversity of aggressive behavior. However, the heterogeneity, polygenic determination, incomplete penetrance of the aggressive behavior have hindered the further exploration into this issue. Through reviewing the candidate genes provided by GWAS studies of diseases related to aggressive behavior both domestically and abroad, the present research intends to perform target regional sequencing on 100 individuals from proactive and reactive aggression group respectively. Then, 400 cases of each category will be collected on a 1:1 case-control study in group validation to investigate the diversity of the susceptibility genes and potential causes and mechanisms resulting phenotypic diversity from the methylation content of epigenetic cases. Data will be analyzed to discuss the interaction among gene-gene, gene-environment, and gene-behavior, as well as to establish risk prediction model for early diagnosis and target prevention.