脑卒中言语产生中感觉运动整合异常的多模态神经影像学研究

脑卒中是成人致残的首要原因，交流障碍中运动性言语障碍发生率超过60%。但临床康复长期缺乏突破性进展，内在神经机制至今不明。言语运动调控是听觉反馈信息与发声运动系统有效整合的结果。脑卒中导致的运动性言语障碍可能与言语产生中听觉感知-发声整合异常有关。据此，本项目拟利用基于听觉反馈扰动的声学技术和事件相关电位分析技术，结合基于脑损伤病灶-行为表现映射的结构磁共振和弥散张量成像技术，研究脑卒中言语产生中听觉感知-发声运动整合的神经机制，从组间水平上阐明脑卒中患者利用听觉反馈调控言语运动的补偿性声学响应模式和皮层诱发电位时-频特性；从个体水平上揭示脑结构网络异常与言语运动调控神经-行为活动之间的相关性。本项目可以明确脑卒中言语运动调控障碍的神经-行为特征及其内在的脑结构基础，有助于从脑损伤的角度理解大脑结构-言语运动调控的内在关联，为使用非侵入性神经调控技术治疗脑卒中运动性言语障碍提供科学依据。

Stoke has become the leading cause of the disabilities in adults, and 60% of stroke patients with communication problems suffer from motor speech disorders. However, clinical rehabilitation of motor speech disorders caused by stroke has not advanced for a long time, and the underlying mechanisms remain largely unclear. Successful control of speech motor behavior is a result of the integration of auditory feedback information with the vocal motor systems. It is speculated, accordingly, that motor speech disorders caused by stroke may be related to the abnormal auditory-motor integration for speech production. With a combination of the altered-auditory-feedback-based psychoacoustics, event-related potential (ERP) methods, the lesion-behavior-mapping-based structural MRI analysis and diffusion tensor imaging (DTI) techniques, therefore, the present project aims to explore the neural mechanisms underlying auditory-vocal integration for speech production in patients after stroke. Our research will show the pattern of vocal compensation and the time-frequency characteristics of cortical ERPs in response to pitch feedback perturbations perceived by adults after stroke during speech production at the group level, and reveal the relationship between abnormalities in the brain structures and neurobehavioral performances in speech motor control at the individual level. Findings from the present project will reveal the neurobehavioral characteristics and the structural basis of speech motor control disorders after stroke and deepen our understanding of the brain structure-speech motor control from the perspective of brain lesion, thereby, providing evidence for the use of noninvasive neuromodulation techniques to treat the motor speech disorders caused by stroke.