玛咖原产南美，具有增强体力、调节免疫等多种生物活性被誉为南美人参，已在我国成功引种并与多种中药配伍应用，但缺乏中药药性理论依据。我们分析玛咖中外文献建立数据库，结合中医药理论提出其中药药性并实验验证，筛选出玛咖多糖为性温味甘健脾的主要活性成分。本研究采用脾虚证模型，以补脾要药人参为对照，从性温考察玛咖、玛咖多糖对脾虚证寒热药性指标及肝、脾线粒体能量代谢酶的影响，用SeahorseXF能量分析系统测肝、脾细胞线粒体呼吸和糖酵解通路；从味甘健脾考察对功效指标的影响，研究免疫细胞因子、骨髓干细胞凋亡蛋白的变化及淋巴细胞增殖与分型；用代谢组学技术筛选代谢标志物并分析通路；从整体、组织、细胞、分子不同层次探讨玛咖影响能量代谢增强体力、调控免疫的物质基础和作用机制。本研究“以证测性”探讨“性效相关”，对积极引导玛咖与中药配伍合理应用现实而迫切，对深入揭示中药药性理论科学内涵、指导临床应用具有意义。

Maca is native to South America, and is known as South American Ginseng because it has a variety of biological activities including physical strength enhancement, immune regulation and so on. Maca has been successfully introduced into China and planted, and used with a variety of traditional Chinese medicinal materials. However, there has been lack of theoretical basis on the issue of Chinese medicine property of maca. We have analyzed the Chinese and foreign literatures and established a literature database of maca. Chinese medicine property of maca combined with traditional Chinese medicine theory and conducted experimental verification have been proposed. Maca polysaccharides were screened as the main active ingredient of maca with warm, sweet and strengthening spleen property. Spleen deficiency model have been established, Ginseng, a major strengthen spleen herb, as control. Then study of hot and heat property indexes of maca powder and polysaccharides and mitochondrial energy metabolism enzymes were explored. Furthermore, methods of analyzing the mitochondrial, glycolytic functionality and metabolic phenotype of hepatocyte and spleen cells by seahorse XF technology were designed. The mechanism of enhancing immunity of maca was investigated by immune cytokines, bone marrow stem cell apoptosis proteins and lymphocyte proliferation and typing based on the sweet and strengthening spleen property of maca. As well as, effective material fundamentals and mechanisms of maca were revealed based on metabolomics technology screening of metabolites and analysis pathway. This study aims to measure the Chinese medicine property based on syndromes, to reveal the correlation between property and effects. It is of great significance for guiding the reasonable maca application compatibility of traditional Chinese medicinal materials. It makes full use of the latest scientific and technological achievements and reveals the clinical application of scientific connotation of traditional Chinese medicine theory.