以G蛋白偶联受体（GPCR）和离子通道为代表的膜蛋白是血管重构最重要的调控网络关键节点，因此也是临床药物的最重要靶点。但面临的问题是研究主要集中在把受体本身作为研究对象，而疾病发生本质是同一受体在生理、病理不同阶段结合不同蛋白形成不同复合体，才导致完全不同的生理和病理状态。因此，血管稳态重构动态过程中的关键环节是受体信号复合体的动态变化。本团队前期发现高血压血管重构中重要的膜蛋白血管紧张素受体I（AT1R）、瞬时受体电位离子通道（TRP）的一系复合体（包括AT1R与TRP通道复合体）等，并对复合体的功能进行了一定程度的研究。本项目将以此为基础利用学科交叉技术及动态分析手段，探究高血压血管重构中关键受体复合体的动态演变规律及以受体复合体为靶点的干预手段。本研究将对其他膜蛋白复合在血管稳态与重构中动态规律及干预提供示范。

Membrane proteins including G protein coupled receptor (GPCR) and ion channels are the most important regulatory network nodes in vascular remodeling, therefore they are also the most significant targets of clinical medicine. However, the essence of disease is that the same receptor binds different proteins to form different complexes at different stages of physiology and pathology, which could lead to completely different physiological and pathological states rather than receptors themselves that main researches focus on currently. Consequently, the dynamic change of the receptor/signal complexes is the key in the dynamic process of vascular homeostasis remodeling. Our team have found a series of receptor/signal complexes of membrane proteins related angiotensin receptor I (AT1R) and transient receptor potential ion channel (TRP) including AT1R and TRP channel complexes in vascular remodeling of hypertension, and also have studied the function of these complex to some extent in our previous works. Based on these, our project will explore the dynamic evolution rules of key receptor complexes in hypertensive vascular remodeling and the intervening strategies targeting receptor/signal complexes by using interdisciplinary crossing techniques and dynamic analysis methods. Our project will demonstrate the standard of dynamic regulation and intervention to other membrane proteins in future vascular homeostasis and remodeling researches.