手性化合物在药物、农药、以及具有生物活性化合物等领域具有重要意义，高效合成手性化合物一直是有机合成的研究重点。Rauhut–Currier（RC）反应是一个高原子经济性的碳碳键成键反应，它可以合成多官能团的有机化合物，而不产生任何副产物。但这一反应存在的主要问题是，交叉RC反应的选择性较难控制，催化剂用量大，反应底物局限性大，本项目针对RC反应选择性的这一科学问题，从催化剂的设计入手，拟设计合成一系列新的多官能团手性有机膦催化剂，研究分子间的不对称RC反应，分子内的不对称RC反应。通过催化剂的设计，发展新的高效催化剂，解决RC反应的选择性问题，合成一系列新的多官能团化合物，环状化合物，为这些化合物的不对称合成提供新方法。同时研究催化反应的机理，为催化剂的进一步设计提供指导。

Chiral compounds have widely applied in pharmaceuticals, pesticides and other bioactive compounds, it is a great challenge that the development of a more efficient method to prepare these kind of compounds.The Rauhut-Currier (RC) reaction is one of the fundamental reaction for carbon-carbon bond formation, it’s also an effective atom-economic method to construct densely functionalized molecules. However, the Rauhut-Currier reactions still have some drawbacks such as the low reactivity and selectivity, higher catalyst loading, limited scopes of the substrates, these drawbacks impede its application in the organic synthesis. In order to overcome these shortcomings, based on our previous work, in this project we will design and syntheze a new kind of multifunctional chiral phosphine catalyst, then, we will focus on the catalysis reaction of these catalyst for the Rauhut-Currier (RC) related reactions, such as intermolecular cross Rauhut–Currier reaction with different active alkenes, intermolecular cross Rauhut–Currier reaction of active alkenes with activated conjugated dienes, intramolecular Rauhut–Currier reaction of active alkenes, the reaction mechanism will be studied by DFT calculation.