腹主动脉瘤发生的机制较为复杂，目前，在基因和药物治疗腹主动脉瘤的研究上并没有突破性进展，我们结合基因工程以细胞治疗为手段，将血管生成素基因（Ang-1）通过腺病毒导入骨髓间充质干细胞中，增强骨髓间充质干细胞在体内的增殖、黏附、迁移和抗凋亡能力。通过构建大鼠腹主动脉瘤模型，移植转基因骨髓间充质干细胞到瘤变处，通过绿色荧光蛋白示踪骨髓干细胞，观察干细胞在动脉瘤壁内迁移、分化的过程，阐明骨髓间充质干细胞在动脉瘤壁内的修复机制。为细胞移植修复动脉壁，减缓动脉瘤生长速度提供新的研究方向。

Abdominal aortic aneurysm(AAA) occurred mechanism is relatively complex. At present, there is no breakthrough research on gene and drug treatment of abdominal aortic aneurysm. We used cell-based treatment as means, transport Angiopoietin-1(Ang-1) into bone marrow mesenchymal stem cells(MSCs) by adenovirus carrier, strength the cells adhesion、migration、proliferation and anti-apoptotic ability in the body. We construct rat's AAA model, transplant transgenic MSCs into aneurysm, observe the process of MSCs migration and differentiation in the aneurysm, explore the MSCs repair mechanism in the process of AAA, show a new research direction on cell-based treatment of AAA.