β-L-鼠李糖苷和α-D-唾液酸苷的合成极富挑战性。本项目将基于本实验室发展的以2-喹啉甲酰基（Quin）为诱导基团的氢键活化策略，首先分别合成一系列以3-或者4-O-Quin取代为特征的鼠李糖和唾液酸糖基供体，再通过对端基活化基、糖环保护基以及反应催化体系和溶剂的系统筛选，最终发展出能高收率、高立体选择性地生成β-L-鼠李糖苷和α-D-唾液酸苷的糖苷化途径，为这两类糖苷键的构建提供新的高效方法。

Syntheses of β-L-rhamnoside and α-D-sialoside are great challenges. Based upon the hydrogen-bond activation strategy using 2-quinolinecarbonyl (Quin) as the directing group which is developed by this laboratory, we will first prepare a series of 3- or 4-O-Quin substituted rhamnosyl and sialyl donors. Then, through extensive screenings of the leaving groups at anomeric centers, the protecting groups, the promoter systems, and the reaction solvents, we will finally develop the highly yielding and stereoselective glycosylation methods for the syntheses of β-L-rhamnoside and α-D-sialoside. This work is anticipated to provide new and efficient approaches for the construction of these important glycosidic linkages.