乙型肝炎病毒(HBV)等诱发因素导致的原发肝癌（HCC）的微创治疗是肝癌治疗研究的热点。光热治疗(PTT)和光动力治疗(PDT)是兴起的治疗HCC的新型微创治疗技术，但由于PTT中热传递的非专属性和PDT中光敏剂在肿瘤细胞低摄取量，限制了这些技术在HCC治疗中的应用。本项目将通过①构建HCC靶向多功能纳米材料以增加肿瘤的光敏剂摄入和靶向热传递，并将其应用于HCC的光热/光动力协同增效联合治疗；②在治疗过程中引入无创实时磁共振(MR)温度监控和MR氧含量测定，以建立MR成像指导下的PTT/PDT效能监测体系，确保治疗的安全性和有效性；③建立HCC联合治疗后的无创MR活体疗效评价体系，明确治疗引起的影像改变的病理学基础和可能的机制。本项目的研究将为建立新的肝癌纳米光热/光动力协同增效联合治疗手段和完善新疗效监测体系提供完整的策略，对提高HCC整体治疗水平以及延长患者生命将有着重要的临床应用价值

There remains an urgent need to develop minimally invasive approaches for hepatocellular carcinoma (HCC) treatment. Photothermal therapy（PTT）and Photodynamic therapy (PDT) represent relatively new approaches for the treatment of HCC. These techniques, however, are limited by the low tumor cells uptake of photosensitizer and the nonspecificity of heat transfer. The study's specific goals are:① To synthesize and characterize graphene-based multifunctional nano-composites to increase tumor cells uptake of photosensitizer and targeted heat transfer. Then HCC will be treated based on photothermal-photodynamic synergistic therapy of graphene-based multifunctional nano-composites; ②To monitor local photo-consumption of oxygen by a tumor using blood oxygen level-dependent MRI to facilitate Photodynamic therapy procedures while concurrently developing and validating a thermal dosimetry model based on quantitative MR temperature imaging (MRTI) for effective and safe treatment; ③To evaluate photothermal-photodynamic synergistic therapy efficacy and relative pathological mechanism by setting up an evaluation system. This stuay will provide new strategy for photothermal /photodynamic synergistic treatment and treatment monitoring. Also this study will be very important for improving and prolonging patients's life.