脑出血（ICH）的致死率和致残率居各类神经系统急症首位，对ICH的继发性损伤及防治研究一直是科研工作者关注的重要科学问题之一。脑出血后血肿占位效应由压迫局部组织形变直接造成组织损伤，还会刺激继发性损伤的发生发展，但血肿占位效应如何影响脑出血继发性损伤及其调控机制尚未清楚。本项目基于实验室脑出血后占位效应力学损伤的研究基础，结合生物力学、神经科学、材料学和分子生物学方法，建立与脑组织材料物理特性和血肿占位病理时空演变相似的力学占位动物模型，选择脑出血后继发性脑损伤的关键因素铁超载为研究指标，探究血肿占位时空效应与脑出血后铁释放、铁沉积和铁损伤的相互作用定量关系，以及力学调控脑出血铁释放、铁沉积和铁损伤的阈值；进而阐明力学-生化耦合效应调控铁超载和细胞损伤途径及分子机制。本项目将进一步揭示脑出血后脑损伤的调控因素和作用机制，可为脑出血新型预警和治疗策略开发奠定基础，具有重要的理论和实际意义。

The mortality and disability rate of intracerebral hemorrhage (ICH) ranks first in all kinds of nervous system emergencies, and the research associated with prevention and treatments of secondary injury after ICH has been one of the important scientific issues. Mass effect induced by hematoma after ICH directly causes tissue damage by compressing local tissue deformation, which can also stimulate the occurrence and development of ICH secondary injury. However, how hematoma mass effect affects secondary injury after ICH and its regulation mechanism is not clear. Based on our previous studies about the mechanical brain damage induced by mass effect after ICH, this project combines biomechanics, neuroscience, materials science and molecular biology methods to establish an animal model used for mass effect research, which is similarity with the physical properties of brain tissue and the space-time evolvement of hematoma pathology. In addition, iron overload, a key factor for secondary brain injury after ICH, will be selected as assessment criteria, and the quantitative relationship between the spatio-temporal effects of hematoma mass effect and iron release, deposition and brain damage after ICH will be studied. Furthermore, the threshold level of iron release, deposition and brain damage induced by mechanical regulation will be investigated, and the regulation approaches and molecular mechanisms of the mechanical-biochemical coupled effect will be clarified. This project will further reveal the regulatory factors and mechanism of brain injury after ICH. It can lay a foundation for the development of new warning and treatment strategies for ICH, which has important theoretical and practical significance.