现在市售药物中25%的分子中含有氟原子。氟、三氟甲基和多氟烷基已成为很多具有生物活性的化合物的结构单元。因此近年来发展了大量的将氟原子和三氟甲基引入到有机分子中的方法。另一方面喹唑啉衍生物表现出多种生物活性，含氟喹唑啉衍生物在药物开发中将占有重要地位。本项目将拓展氟化、三氟甲基化的方法，在此基础上发展全新的向有机分子中引入全氟烷基砌块的新方法、发展远程控制碳-氢活化导向氟烷基化新方法，合成一系列具有潜在生物活性的含氟喹唑啉衍生物，以满足药物筛选工业的需要。

About 25% of commercially available drugs contain fluorine atom(s). Fluoro, trifluoromethyl, and polyfluoroalkyl group have become a structural unit for a lot of biologically active compounds. Therefore a number of new methods have been developed for the introduction of fluoro and trifluoromethyl group into organic molecules in recent years. On the other hand, the quinazoline derivatives exhibit a variety of biological activity, and the fluorine-containing quinazoline derivatives will occupy an important role in drug development. This project will expand the method to introduce fluoro and trifluoroethylene group, to develop new method to introduce polyfluoroalkyl group as building block of the organic molecules, and to develop new fluoroalkylation method through remotely controlled carbon-hydrogen bond activation. We will make a series of potentially bioactive fluorinated quinazoline derivatives, to meet the needs of the drug screening industry.