金属催化导向C-H键活化反应被认为是有机合成中最经济有效的手段。本课题拟发展一种新的氮氧偶极子导向催化碳-氢键活化串联反应，在不同条件下分别高选择性构建两类新型异喹啉功能杂环分子。在有水条件下，2,4-二芳基喹唑啉氮氧偶极子与一分子芳炔反应高产率合成1-(2-N-酰胺基)苯基-2,3-二芳基异喹啉衍生物。而在无水条件下，2,4-二芳基喹唑啉氮氧偶极子与二分子芳炔反应，高产率合成8-氨基-1,3,4-三芳基异喹啉-2,3-二芳基茚酮亚胺; 我们将对上述两类异喹啉化合物进一步衍生化，合成新的稠环杂环分子、含氮双齿配体及其氟硼化合物。对这些功能杂环分子的光物理性质进行评价，筛选出效果好的化合物分子，研究它们在金属离子的识别、金属离子检测、有机发光二极管、聚集诱导发光、溶致变色、离子传感、细胞成像、光动力学治疗等领域中的应用。

Metal-catalyzed C-H activation has been widely recognized as a step-economic strategy in organic synthesis. We plan to develop a new N-oxide directing catalytic C-H activation tandem reaction. In this reaction, two kinds of new functional heterocyclic molecules were selective synthesized under various conditions. In aqueous solvent, 1-[2-(3,4-diaryl-isoquinolin-1-yl)-phenyl]-benzamides were obtained in excellent yields by the reactions of 2,4-diarylquinazoline-N-oxides with alkynes. Under anhydrous condition, 2,4-diarylquinazoline-N-oxides reacted with two mole alkynes to selective produce (2,3-diaryl-inden-1-ylidene)-(1,3,4-triaryll-isoquinolin-8-yl)-amines in one step. More new functional isoquinoline contained heterocyclic molecules, such as fused heterocyclic compounds, N,N- chelating ligands and their organoboron complex, were obtained deriving from 1-[2-(3,4-diaryl-isoquinolin-1-yl)-phenyl]-benzamides and (2,3-diaryl-inden-1-ylidene)-(1,3,4-triaryll-isoquinolin-8-yl)-amines. The photo-physical properties of these synthesized functional heterocyclic molecules were evaluation. Good organic opto-electronic functional molecules were screen out by these evaluations and their application in aggregation induced emission (AIE), solvatochromism, ion sensing, cell imaging, photodynamic therapy(PDT) were investigated.