高分子基骨替代材料虽具有良好的生物相容性和生物活性，但由于力学性能的不足，限制了其在承重骨替代领域的应用。材料结构学证实骨基本单元定向有序规则排列所构筑的层级结构是天然骨优异力学性能的本质原因，通过模仿天然骨的组成和结构特征获得仿生人工骨因此成为当今生物材料研究的前沿课题。本项目拟将仿生原理与高分子加工定构相结合：在注塑过程中，利用可控的强剪切流动场诱导高分子骨修复复合材料的高分子组分生成大量取向自增强结构（如串晶、互连串晶等），其在结构上类似于天然骨的胶原纤维束，实现结构仿生。在不影响材料生物活性的前提下，大幅度提高力学性能，从而满足承重骨替代的性能要求。揭示加工外场参数对仿生自增强结构生成与演化的影响规律，建立高分子基仿生骨“加工-仿生结构-性能”关系，系统评价仿生骨的生物学性能，为制备高性能高分子仿生骨提供理论指导和技术支持。

Due to the insufficient mechanical performance, the application of polymer bone substitutes has been limited to none or minor load-bearing fields despite their good biocompatibility and bioactivity. It has been well established that the outstanding mechanical performance of natural bone stems from the ordered hierarchical structure of bone units, which align in a preferred orientation. Thus, mimicking the composition and structural features of natural bone provides possible design solutions for fabricating the artificial bone and becomes a hot frontier in today’s biomaterial science. In this proposal, we plan to make a combination of bionic principles and structure manipulation to prepare the biomimetic polymer bone. In the injection molding, a controllable and intense shear flow is employed to induce a large amount of oriented self-reinforced superstructure, i.e., shish-kebabs and interlocked shish-kebabs, which share the structural similarity with the aligned collagen fiber in the natural bone. Under the premise of holding the biological properties, the considerable mechanical reinforcement is gained, enabling the prepared bone-mimetic composites to serve as moderate or even major load-bearing bone substitutes. We intend to reveal the effects of processing fields on the formation and regulation of the biomimic self-reinforced superstructures, further setting up the “processing-bionic structure-performance” interrelation. The biological performance is also evaluated. The obtained fundamentals will offer theoretical guidelines and technical assistance for manufacturing biomimetic polymer bone with superior mechanical performance.