双功能Lewis酸可通过与底物生成σ-和π-络合物，在"一锅煮"的条件下催化不同的环化反应，在连续环化反应中是非常有用的催化剂。我们最近研发出一种双功能Lewis酸催化的DA/carbocyclization连续环化反应，能快速地构建一系列具有全碳季碳手性中心的高度官能团化的cis-hydrindanes。因此，本课题的目标是基于这种新的策略，发展第二代的双功能Lewis酸催化的DA/carbocyclization连续环化反应，使之成为一个通用的合成方法。能以简单的原料，在"一锅煮"的条件下快速地构建6,6,5-及6,6,6,5-并环体系，并应用于合成多种与ent-kaurene（对映体-贝壳杉烯）结构相关，而且具重要生物活性的天然产物，包括platensimycin、platencin、trichorabdal A和maoecrystal Z。

Bi-functional Lewis acids can catalyze different cyclization reactions in one-pot via forming σ- and π-complexes with the substrates. Recently, you have developed a bi-functional Lewis acid catalyzed DA/carbocyclization cascade cyclization reaction, which can rapidly construct a series of highly functionalized cis-hydrindanes with all-carbon quaternary stereogenic center. Base on this new strategy, the objective of this project is to develop the second generation bi-functional Lewis acid catalyzed DA/carbocyclization cascade cyclization reaction into a general synthetic method, which can construct the 6,6,5-and6,6,6,5-fused ring systems from simple substrates in one-pot for synthesis of ent-kaurene related natural products with important biological activities, including platensimycin, platencin, trichorabdal A and maoecrystal Z.