心脏再生是再生医学领域尚未被征服的冰山，探索促进心脏再生的分子机制具有重要意义。我们前期研究发现ADAR1和microRNA-222可以促进心肌细胞增殖，并且发现ADAR1可以调控microRNA-222，但是ADAR1在心脏再生中的作用尚不清楚。本项目拟在细胞和动物水平上进行功能获得性和缺失性实验，明确ADAR1与心脏再生的关系。然后通过功能逆转实验，证实ADAR1是否通过microRNA-222调控心脏再生。最后，探索ADAR1是否可以通过促进心脏再生来防治心力衰竭。本研究将明确ADAR1在心脏再生中的作用，为心力衰竭的细胞替代和药物开发提供理论基础。

Heart regeneration is an unsolved challenge in regenerative medicine field, and it is of great importance to find pivotal factors boosting heart regeneration. Our previous work reveals that ADAR1 and microRNA-222 could enhance cardiomyocyte proliferation. We have identified ADAR1 as up-stream regulator of microRNA-222, but the role of ADAR1 in heart regeneration remains unknown. This program will conduct gain of function and loss of function experiments on cell and animal level to verify the regulation of ADAR1 on heart regeneration. Through functional reverse experiment, we will prove if ADAR1 regulate heart regeneration via microRNA-222. In the end, we will explore if up regulation of ADAR1 could prevent heart failure. This work will explore roles of ADAR1 in heart regeneration and provide theoretical foundation for cell therapy and drug development of heart failure.