肺造血免疫介导的室内细颗粒物致心血管系统危害特征的研究

室内空气污染是引起心血管系统疾病发生和死亡的环境因素，华北地区由于地理环境和气候特点，形成了重污染水平的室内空气污染特征。虽然人群流行病学提供了室内空气污染与心血管疾病的关联，但因实验室机制研究证据缺乏导致其健康效应特征及机制不清。本项目建立随机对照设计结合空气净化干预的室内空气颗粒物和VOCs暴露的人群研究以及真实环境室内颗粒物和VOCs暴露的动物模型。首先，分析室内空气污染物暴露与心血管损伤的关联，解析华北重污染地区室内空气污染及健康危害特征；其次，通过课题组已经建立的在体-离体（ex-vivo）生物感受细胞模型，将人群、动物与细胞间的介尺度机制研究建立直接有效的物质联系；第三，从肺造血免疫轴介导的系统炎症机制入手，阐明室内空气污染对心血管系统损伤的机制，为解析华北地区室内空气污染的健康效应特征，制定室内空气质量标准，减少因环境因素导致的心血管系统疾病提供十分重要的依据。

Indoor air pollution poses a risk to cardiovascular health. Because of geographical environment and climatic characteristics, the indoor air quality is compound pollution with high level pollutants in North China. Although epidemiological study provides an association between indoor air pollution and cardiovascular diseases, the mechanism of cardiovascular diseases induced by indoor air pollution has not been known clearly. We propose to conduct randomized control trial with air purification intervention and real-world particles and VOCs exposure animal model for three aims: 1) To assess the association between indoor air pollution and cardiovascular damages. To identify the characteristics of indoor air pollution and health hazards in the heavily polluted North China. 2) The mesoscopic scale mechanism between human, animal and cells will be studied to establish a direct and effective material connection by ex-vivo biosensor model. 3）The mechanism of systemic inflammation mediated by pulmonary hematopoietic immune axis will be analyzed to clarify the mechanism of indoor air pollution on cardiovascular injury. To analyze the characteristics and possible mechanism of cardiovascular diseases caused by indoor air pollution in North China. It will inform environmental regulations and help reduce cardiovascular diseases caused by environmental factors.