白内障手术和人工晶状体（IOL）植入后存在细菌性眼内炎、后发性白内障等并发症，严重损害患者视力恢复，改变IOL的材料学特性降低术后并发症是近年来国内外重要的研究课题。我们已经设计、合成了P（FPOSS-MMA-DMAEMA）三元共聚物，对PMMA IOL进行本体改性，透光率超过95%。本课题将对材料进行季铵盐化处理，形成聚阳离子抗菌官能团，并通过等离子体刻蚀制成仿荷叶超疏水表面。考察材料的结晶性、力学和热力学性能，探究材料化学组成、结晶性与透光性的关系。进一步，进行体外的生物学评价，明确季铵盐组分的抗菌功能和超疏水表面的抗黏附性能，揭示材料组成、微观结构和表面功能的关系。最后，通过动物实验研究材料的抗菌性和生理相容性，阐明复杂生理环境对材料生物学功能的影响。因此，该研究在生物医用材料改性上具有重要的科学意义，对IOL植入后防止各类并发症也有很重要的临床应用价值。

Bacterial endophthalmitis, posterior capsule opacification (PCO) and other complications are common after cataract surgery. Changing the surface properties of intraocular lens (IOL) to reduce postoperative complications is an important international research topic in recent years. To modify PMMA IOL, P (FPOSS-MMA-DMAEMA) terpolymer was designed, synthesized and made it into IOL with transmittance of more than 95%. Next, we will do quaternary treatment of DMAEMA to form polycationic antibacterial groups and plasma etching to made lotus imitation micro-nano composite structure. Then, the impact of composition and synthetic conditions on the crystallinity, light transmittance, mechanical and thermodynamic properties of IOL will be explored. Further, in vitro antibacterial and cytological evaluations will be done to clarify antibacterial and anti-adhesion properties of IOL and reveal the relationship of microstructure and surface features. Finally, the animal studies will be done to illustrate the effect of physiological conditions on the biological functions of IOL. In conclusion, this study aims to achieve complex functional IOL through body modification and provide new idea for the design of advanced functional IOL. So this study not only has important academic significance on the biomaterials modification, but also has a practical significance on prevention of bacterial endophthalmitis and PCO after IOL implantation.