本项目将开展基于螺环吡咯烷结构的手性小分子和金属配合物催化剂的设计、制备和合成应用研究，重点开展对新颖高效不对称串联Mannich/酰胺化、Michael加成/环化、双烷基化等反应的探索，并将这些串联反应运用于加兰他敏、吗啡、二聚六氢吡咯吲哚等复杂多环天然产物的全合成当中。该项目将完善提升普适性强的螺环吡咯烷催化剂，对构筑多环多中心的不对称合成方法学发展具有重要的学术意义，在天然产物和药物分子的合成中有潜在的工业应用价值。

This project aims to explore a novel type of spiropyrrolidine-derived organo and organometallic catalysts. The design, preparation, and synthetic application of these catalysts will be investigated, with a focus on the development of novel and efficient asymmetric tandem reactions, such as Mannich/amidation, Michael addition/cyclization, dialkylation reactions, which will be further applied in the total syntheses of complex polycyclic natural products such as galanthamine, morphine,and hexahydropyrroloindole. The project will enable the improvement of more general spiropyrrolidine catalysts that are beneficial to the development of asymmetric synthetic methodologies for the construction of polycyclic carboskeleton, which is of great academic importance as well as potential industrial value for the synthesis of natural or pharmaceutical molecules.