基于组织内相变微泡振动模型参数反求的微弹性成像

基于现有组织超声弹性成像需外部施压或内部生理波动及不适用于体内小目标成像的局限，本项目（1）提出以组织内相变微粒导入及尺寸控制为基础的相变微泡动力学模型及模型参数反求理论方法，研究微泡振动过程与其周围微米尺度组织弹性的关系。（2）发展以组织内相变微泡动力学为基础的组织中稀疏微泡高信杂比、高分辨、高速超声成像及基于参数反求的微弹性成像技术。（3）针对静脉血栓超声溶栓及肿瘤新生微小血管毁损过程中的组织力学参数成像需求，研究相变微粒的在体导入及微泡信号检测技术，基于组织内相变微泡振动模型参数反求发展可指导治疗的微弹性成像技术。由此形成从物理机制、理论方法和应用对象等方面与现有弹性成像完全不同并具有重要应用价值的微弹性成像技术，推动组织弹性成像这一重要领域的发展。

In order to overcome the limits of common elastography, such as the need of external pressure or internal physiological fluctuations, are inapplicability for small targets in the body, this project (1) proposes to construct a bubble dynamics model for phase shift nano-emulsions within the tissue and the inverse solution of model parameters based on controlled particle delivery into the tissue and their size regulation. By this method, the relationship of bubble oscillation and the elasticity of surrounding tissue can be studied. (2) Based on phase shift nano-emulsions dynamics in tissue, this project wants to develop a micro-elastography technique with high signal to noise ratio, high resolution and high imaging speed, for sparse microbubbles in tissue. (3) It also aims to study the in vivo particle delivery technique, the inversion parameter solution of phase shift nano-emulsions model in tissue and micro-elastography technique which can guide treatment on thrombolysis of venous thrombus and vascular destruction of tumor neovascular. Thus, a micro-elastography technique which is quite different from the common elastography in physical mechanisms, theoretical approaches and applicant objects can be created. This technique has significant application value, and would promote development of tissue elastography.