近年来，随着新型计算领域的快速发展，DNA密码的研究已经成为前沿研究热点。其中，结合纳米颗粒技术的分子计算信息处理方法也逐渐引起学者们的重视。本项目尝试结合DNA纳米颗粒技术，并利用自组装、链置换等手段，对纳米颗粒密码计算模型进行多角度多层次研究，使得DNA密码技术从理论走向实用。结合DNA自组装技术，自上而下进行模块化特异性集成，获得不同结构纳米装置的基底结构。再利用化学修饰与分子识别，完成纳米颗粒与DNA自组装体的结合。随后，通过模块集成和组装，构建分子密码器件。最后，借助荧光和电镜等多重检测，通过集成和空间排布，构建多重多层分子密码装置，实现其计算功能。通过本项目，使得分子密码计算模型早日走出实验室，为构建通用性专用分子密码系统奠定基础。

In recent years, with the rapid advance in the field of DNA computing, DNA cryptography has become a research focus. Particularly, molecular computing combined with nanoparticles has attracted much attention from lots of researchers. In this project, combined with DNA nanoparticles, we will construct a molecular cryptography model. Through multiple researches, the methods of self-assembly, strand displacement are introduced, which make DNA cryptography approached to application. Making use of DNA self-assembly, a variety of nanostructure substrate is developed. After that, the substrate is conjugated with nanoparticles by molecules recognition. Though multiple assembled among presented modules, a molecular cryptography device is produced to carry out computations. In this way, the molecular cryptograph model would be applied from theory to practice, which will establish the foundation for constructing universal molecular cryptosystem.