全民食盐加碘（USI）实施以来，我国居民碘营养得到显著改善，但由于孕妇对碘的特殊需求以及我国高水碘地区和病区的自然分布，使得我国孕妇正遭受碘缺乏和碘过量的双重危害。目前国内缺乏孕妇碘推荐摄入量（RNI）和可耐受最高摄入量（UL）的基础研究，只能借鉴国外数据。因此，我们在前期成人碘UL研究及高碘地区孕妇碘营养的流行病学调查等工作基础上，一方面拟对健康孕妇在个体水平进行碘平衡研究，分析碘平衡状态与碘摄入量的关系，推导健康孕妇碘的RNI；另一方面拟对不同孕期轻微碘缺乏孕妇和不同高碘暴露的孕妇在人群水平进行随访监测，探讨不同碘摄入量对母体及子代的影响，判定我国孕妇碘的UL。即综合个体和人群两个水平，系统地研究不同碘摄入量对健康孕妇及后代的影响，以明确我国孕妇碘的RNI和UL，为我国人群碘DRIs的修订提供第一手的资料，同时也为孕期碘缺乏和碘过量危害的防治工作及USI持久科学地实施奠定研究基础。

With the implementation of Universal Salt Iodization, iodine nutrition status for Chinese people has been improved remarkably. However, pregnant women are suffering from both iodine deficiency and iodine excess due to special iodine requirement of pregnancy and wide natural variation in water iodine levels in China. The RNI and UL for pregnancy in China was set by extrapolation from foreign data, as it was lack of actual RNI and UL research for pregnancy. Basing on previous research on iodine UL for adults and epidemiological survey on iodine nutritious status of pregnancy in high iodine areas, on one hand, we will conduct iodine balance study on healthy pregnant women individually, analyzing and deducing RNI for healthy pregnant women. On the other hand, we will carry out a survey on thyroid function of pregnant women with mild iodine deficiency and excessive exposure in high iodine areas at different levels, providing suggestion on iodine supplementation for pregnancy with excessive iodine intake in each stage; safety intake of iodine for pregnancy would be set with this prospective study on the effect of iodine intakes on maternal and infant health. The establishment of EAR and UL, based on synthetically studying the effects of iodine intakes on maternal and infant health from both individual level and population level, will not only provide data foundation to revision of DRIs of iodine in China and prevention of pregnancy hazard caused by iodine deficiency and excess, but also guarantee a scientific and long-term iodized salt supplementation.