"黄海2号"是经连续9代选育的中国对虾养殖新品种，在抗WSSV性能测试中，发现其对WSSV有显著抗性（可耐受低于1万WSSV拷贝的病毒量）；也同时发现重复感染WSSV的存活率显著提高，似乎有"类免疫"保护功能。"黄海2号"抗性究竟单纯源于遗传，还是掺有"类免疫"保护作用？"类免疫"可否遗传？本课题拟以连续选育的"黄海2号"和未经选育的野生对虾为研究对象，通过比较两者（以及次年开始产生的"类免疫"子代）耐受WSSV能力和在二次人工感染后"类免疫"保护差异，研究"类免疫"保护对中国对虾产生WSSV抗性的作用；同时利用课题组前期研究已获得的SNP标记和基因芯片分别进行关联分析，深入探讨"类免疫"保护的分子基础。研究结果将首次阐释"类免疫"保护在对虾产生WSSV抗性中的作用和机理，为其与良种选育有效结合、进一步提高中国对虾抗病性提供理论依据。本研究思路还将对其他虾、蟹类抗病研究起到良好示范作用。

The "Huanghai No. 2" is the new culture variety of Chinese shrimp (Fenneropenaeus chinensis) which was obtained after nine-generation successive selective breeding. In its WSSV challenge test, it showed high WSSV-resistance ability significantly that it can tolerate less than 10,000 WSSV copies. Besides this, it's found that the survival rate was improved significantly when they were challenged by WSSV once more, seemed like this new variety showed special function called "quasi-immune protection". We are wondering that if the WSSV-resistance ability of "Huanghai No. 2" was generated from the heredity alone? Or incorporated with "quasi-immune protection"? And can "quasi-immune protection" function be inherited? The present study was supposed to compare the WSSV-resistance ability and the difference of "quasi-immune protection" when challenged and re-challenged by WSSV using the two populations of "Huanghai No. 2" and nature population without selection background, as well as the filial generation of "quasi-immune" survivals next year; and to research the effects of WSSV-resistance function generated from "quasi-immune protection". Furthermore, in order to investigate the molecular basis of "quasi-immune protection" in a deep-going way, association analysis will be conducted using SNP markers and gene chips respectively which have been achieved by our study in prior period. The results of the present study will illuminate the effects and mechanism of "quasi-immune protection" in WSSV resistance in F. chinensis for the first time, which will provide the theoretical foundation for combining the "quasi-immune protection" with selective breeding and will improve the WSSV-resistance ability further. The concept in the present study will be a good demonstration for researchers when studying the disease resistance in other shrimps and crabs.