环境中药物和个人护理品（PPCPs）来源复杂，但对其污染源贡献的研究不足。加强PPCPs污染源解析研究，发展源解析定量方法是当前面临的新课题，而合适的示踪物质是源解析的关键。大多数PPCPs是手性异构体，手性特性表明它们适用于污染源示踪。研究拟建立复杂环境样品的手性PPCPs对映体分析方法，通过实验室模拟和采样分析筛选合适的手性PPCPs示踪物。通过对北京温榆河-北运河流域的采样分析，揭示其在各种污染源和地表水中的存在特征和归趋、以及手性环境行为，建立不同来源污水和受纳水体中手性PPCPs的对映体指纹谱，结合对映体指纹谱和化学质量平衡模型（CMB），建立新的源解析方法，进行PPCPs污染源解析，探讨不同排放源对水环境中PPCPs污染的贡献。本研究将扩展PPCPs区域环境行为研究及源解析方法，为PPCPs区域风险评价和控制提供科学依据，促进流域水环境安全管理。

The pollution sources of pharmaceuticals and personal care products (PPCPs) in the environment are complex, but till now, there is a lack of quantitative analysis of the various sources contributing to the PPCP pollution. For this reason, their pollution source study should be conducted. The development of quantitative source apportionment method is the urgent issue. To find suitable tracers is the key solution. A lot of PPCPs are chiral, which suggests the enantiomers are available for tracing PPCP pollution source. The aim of the study is to establish an enantiomeric analysis method for chiral PPCPs in complex environment matrix, then select suitable tracers based on laboratory simulation and field sampling. The occurrence characteristics of PPCPs will be obtained by sampling at the Wenyu-Beiyun basin, revealing the distribution, fate and the enantioselective environmental behaviors in various sources and surface water. Based on this, the enantiomer fingerprinting of chiral PPCPs in different wastewater sources and receiving waters will be built. Combined with the Chemical Mass Balance（CMB）model, a new method for PPCP source apportionment will be established. Accordingly, the PPCPs pollution sources can be analyzed, and the pollution contribution from different sources can be calculated. Our research will broaden the horizon on PPCPs regional environmental behavior and extend the source apportionment technique, and thus provide scientific basis for regional risk assessment and control of PPCPs, thereby help to promote water environment safety management.