基于新概念的手性催化剂的设计是不对称催化领域的一个重要研究热点。尽管我们在基于二氢咪唑并吡啶骨架的亲核催化剂和手性N,O-配体的设计和应用方面取得了一定的突破，但是还存在反应和底物适用范围较窄，催化剂的不对称诱导效果有待于提高等问题。为此，本项目致力于设计一类具有潜在（伪）轴手性元素的新型含氮亲核催化剂，以及具有氢键导向基团的伪轴手性双功能亲核催化剂，希望通过手性的空间传递来实现中心手性与伪轴手性的柔性匹配；同时希望把这类新型亲核催化剂应用于芳基取代烯丙醇、二级胺和氨基醇的动力学拆分，内消旋二醇的去对称化，烯酮的不对称质子化，具有α-亚甲基的羧酸对活化烯烃的不对称Michael加成等一系列催化反应中；另外，我们还将结合实验数据和理论计算来阐明轴手性基团影响反应的立体选择性的因素，并以该结果为理论指导设计更为高效的催化剂用于各种类型催化不对称反应中，从而为高效手性催化剂的设计提供新的思路。

New concept based design of chiral catalysts and ligands is a current hot research project in the field of asymmetric catalysis. Although we have made great progress in the design of dihydroimidazopyridine based nucleophilic catalysts / chiral N,O-ligands and their applications, there are still some limitations, such as narrow scope of corresponding reactions and substrates, further improvement of the asymmetric induction. In order to circumvent these issues,a new concept, pseudo-axial chirality, was proposed in this project. we are going to design a series of N-containing pseudo-axial nucleophilic catalysts, and hydrogen-bond directed bifunctional nucleophilic catalysts, by doing this, we hope the pseudo axial chirality can match (or induced fit) with center chirality via chiral delay. We also would like to apply all these new catalysts for a variety of asymmetric catalysis such as the KR of aryl allylic alcohols, secondary amines and aminoalcohols; desymmetrization of meso-diols; asymmetric protonation of ketene; asymmetric addition of α-methenyl carboxylic acid to activated alkenes etc.. Most importantly, we hope that the concept of pseudo-axial chirality can be proved with the combination of experimental data and theory calculation,and the mechanistic path of reaction steroselectivity can be confirmed, which in turn paves the new path for the design of new chiral catalysts or ligands for asymmetric catalysis.