近年来有机催化概念的提出大大促进了有机催化反应的发展，并已成为不对称催化领域的重要研究热点。其中，全新骨架的催化剂设计和新立体控制模式的提出已成为有机催化研究领域的两条核心研究思路。申请人在前期研究中发展了一种高效，高立体选择性N,O-配体/Cu(II)催化的新型1,3-偶极环加成反应，并合成得到一系列螺环吡咯烷衍生物。鉴于该螺环吡咯烷骨架的结构新颖性和其独特的手性环境，本项目致力于设计并合成一系列结构新颖，不对称诱导能力更强的螺吡咯烷类有机催化剂，并借助其手性诱导基团的多样性和立体控制模式新颖的特点，应用于一系列新型的基于“烯胺催化”和“亚胺离子催化”的不对称催化反应中，以期解决目前有机催化中的非对映选择性调控问题，以及一些催化反应中对映选择性不够理想，尤其是远程立体控制较难实现的问题。本项目研究不仅有望为发展一系列高效的有机催化体系奠定科学基础，并有望为手性技术的发展提供新的催化剂设计思路。

The recently described concept of organocatalysis greatly promoted rapid advance of organocatalytic reactions, and now has been considered as an important research field in the area of asymmetric catalysis. Among them, the design of new catalyst scaffold and novel steric controlling mode have been recognised as two core research methods for the development of new organocatalytic reaction system. In previous work, we have developed a highly efficient and stereoselective 1,3-dipolar cycloaddition catalyzed by a N,O-Ligand and copper complex, which provided a series of spiro-pyrrolidine derivatives in high yields. In view of the structurally novelty of spiro-pyrrolidine scaffold and the unique chiral environment, we are dedicated to the design and synthesis of structurally novel spiro-pyrrolidine organocatalyst having better steric controlling ability, which will be applied for a series of "enamine catalysis " and "iminium catalysis" based asymmetric catalytic reaction by the utilization of these spiro-pyrrolidine catalysts featuring diverse chiral substituents and new steric control mode. The project proposed herein is expected to be able to address the issues of current organocatalytic reactions, for example the difficulty in diastereroselectivity control, relative low enatioselectivities in some reaction, especially the long-distance steric control problem. In conclusion, this project could lay the foundation of developing highly efficient organocatalytic system, which in turn provides a new thinking in the design of chiral catalysts for the development of chiral technology.