我们的研究发现单色绿光刺激肉鸡肝脏分泌IGF-1，后者与肌肉组织中IGF-1受体结合，促进骨骼肌卫星细胞增殖和分化。但对外界光色信息如何影响鸡肝脏IGF-1的合成与分泌的机制仍不清楚。本项目以前期发现单色光影响褪黑激素分泌为切入点，探究单色光影响鸡肝脏IGF-1分泌与褪黑激素及受体表达的相关性；确定在单色光影响鸡肝脏IGF-1的合成与分泌中，褪黑激素是否发挥介导作用及其作用的膜受体途径、膜-核受体信号通路、胞内信号途径和PKA/ERK与JAK2/STAT3信号的串扰作用等。本研究在经典学说认为肝脏IGF-1分泌受下丘脑-垂体生长激素-IGF-1轴调控的基础上，阐明外界光色信息通过褪黑激素直接作用于鸡肝细胞影响IGF-1的合成与分泌的新路径及其分子作用机制，有助于揭示环境因子（光色）影响机体功能基因表达的内在联系，有望为合理利用光色信息提高家禽生产力提供新的突破点。

Our previous studies found that monochromatic green light stimulated IGF-1 secretion in the liver, and IGF-1 combined with its receptors within muscle tissue to promote the proliferation and differentiation of skeletal muscle satellite cells in broilers. However, how the environmental color light information influence the synthesis and secretion of IGF-1 is not clear. The project will investigate the correlation between IGF-1 secretion and expression of melatonin and its receptors, and discuss whether melatonin plays a mediating role of synthesis and secretion of IGF-1 in broiler liver under monochromatic light, and determine the role of melatonin membrane receptor pathways, membrane-nuclear receptors signaling pathways, and crosstalk between PKA/ERK and JAK2/STAT3 signals in affecting by monochromatic light in broiler liver. The study is on the basis of the classical theory, the liver IGF-1 secretion regulated by the hypothalamus – pituitary growth hormone – IGF-1 axis, to clarify the new pathway and molecular mechanism of liver IGF-1 synthesis and secretion in enviromental color light information via the direct effct of melatonin in boriler. Therefore, the project will be helpful to reveal the internal relationship between the environment factors (such as light spectra) and the avian functional gene expression, and is expected to provide a new theoretical guidance in improving the productive performance in poultry by using new light spectra.