A类清道夫受体介导的巨噬细胞极化在心血管疾病微环境中的作用及其机制研究

单核-巨噬细胞的极性分化决定了慢性炎症的反应趋向，在许多疾病的发生发展中发挥重要的作用。我们的前期研究结果证明，巨噬细胞的极性分化可能受A类清道夫受体（SR-A）的调控，其功能异常与缺血性心脑疾病的发生发展关系密切。在此基础上，本项目拟进一步研究SR-A介导的巨噬细胞极化在心血管病和糖尿病微环境中的作用及其机制。主要研究内容包括筛选发现能诱导巨噬细胞极化的SR-A新的脂质类配体，阐明SR-A调控巨噬细胞极化的代谢途径及其与其他受体之间可能的协同作用。本研究有助于全面认识在疾病微环境中巨噬细胞的作用及其调控机制，还可为相关疾病的干预提供新的靶点。

The monocytes/macrophages polarization determines chronic inflammation trend that plays a very important role in many diseases. We have found that macrophage polarization is regulated by class A scavenger receptor (SR-A). Abnormality in SR-A function is closely associated with ischemic diseases in the heart and the brain. Based on it this project will further investigate SR-A-mediated macrophage polarization in the micro-environments in cardiovascular diseases and diabetes mellitus. The major contents of the research will cover that: identification of new SR-A lipid ligands inducing macrophage polarization, elucidation of the SR-A pathway regulating macrophage polarization and discovery of novel synergic effect between SR-A and other pattern recognition receptors. These studies are useful to get insight into macrophages in disease micro-environments and to provide potential target for interference with diseases.