心脏能耗需求高，代谢底物广，反应过程易受多种因素的影响。在心脏疾病的发展过程中，不仅心肌细胞代谢发生重编程，非心肌细胞特别是巨噬细胞的代谢也发生显著的变化。它们共同作用的结果，导致心脏大小、形状、结构和功能发生异常改变。然而在心脏病理性重构中，不同细胞的代谢重编程特性和彼此间的关联仍不清楚。我们和他人的前期研究结果表明，模式识别受体（PRRs）不仅调控巨噬细胞活性的改变，而且介导心肌细胞的损伤反应和心脏微环境的改变，提示其可能在整合心脏不同细胞的代谢和免疫反应中发挥重要作用。本项目拟研究PRRs及其偶联蛋白MVP等介导的心肌细胞和巨噬细胞的代谢重编程特征及其对功能的影响，探讨脂质等代谢底物对细胞代谢、炎症反应和表型特征的影响，刻画心脏微环境中细胞对话的分子本质。本项目对于揭示心脏病理性重构中细胞代谢重编程的变化特性和内在规律、发现新的干预靶标具有重要的理论意义和应用价值。

During the process of pathological cardiac remodeling, metabolic reprogramming takes place not only in the cardiomyocytes, but also in non-cardiomyocytes, especially in macrophages. The metabolic changes in various cardiac cells contribute to pathological alters in cardiac size, shape, structure, and function. However, the characteristics of metabolic reprogramming in cardiac cells and the relationship between them in pathologic cardiac remodeling are not fully understood. Our previous studies and others' indicated that the pattern recognition receptors (PRRs) not only regulate the functions of macrophages, but also mediate the injury of cardiomyocytes and shape cardiac microenviroment. This project intends to perform the researches on the effects of PRRs and their intracellular coupling protein MVP on cardiac remodeling. We will analyze the metabolic characteristics of cardiomyocytes and macrophages and subsequent functional and phenotypic switch, explore the influence of metabolic lipid substrates on cellular metabolism, inflammation and functions, and depict molecular basis for the dialogue between cardiomyocytes and macrophages in cardiac niches. It will be of great theoretical significance and potential clinical application value in revealing the change properties and intrinsic mechanisms of cellular metabolic reprogramming in pathological cardiac remodeling and discovery of novel interventional target.