"前期高血压"是高血压形成之前的一个重要病理过程。本研究以"未病先防，既病防变"的思想为指导，以应激性前期高血压大鼠模型为对象，采用全基因芯片、蛋白质组学技术等，针对应激性前期高血压不同时间点给予针刺干预，以观察不同针刺方法对应激性前期高血压大鼠模型的降压及器官保护效应；运用系统生物学技术构建针刺调控网络通路并进行通路分析，对参与针刺调控的关键通路进行验证，揭示针刺调控应激性前期高血压的干预靶点及效应机制，为高血压病的防治提供科学依据。

"Pre-hypertension" is an important pathological process before the formation of hypertension.In this study , using the idea "prevention before disease, illness prevention " as guidance and stress-induced pre-hypertension rat model as object, using gene chip, proteomics technology, we give acupuncture intervention against stress-induced pre-hypertension at different time points, then we can observe the effects of different acupuncture methods on stress-induced pre-hypertension rat model and organ protection; operate system biology technology to construct the acupuncture regulation network path and path analysis, test and verify the key pathway in acupuncture regulation, then we can reveal the intervention target and effector mechanisms of acupuncture regulation of stress-induced pre-hypertension, and provide a scientific basis for the prevention and treatment of hypertension.