了解肿瘤与衰老的关系,已成防治肿瘤的重要前提之一。肝细胞癌（Hepatocellular carcinoma, HCC）是肝癌的主要类型,是癌症致死的重要原因之一。细胞衰老抑制基因（cellular senescence-inhibited gene，CSIG）是本实验室克隆而得的基因,在人类多种年轻细胞中高表达，衰老细胞中低表达。CSIG过表达可明显延缓细胞衰老，这种功能依赖其对PTEN翻译的调控。近来我们发现CSIG可促进HepG2和SMMC7721等人类肝癌细胞的生长，引起癌基因c-Myc表达。本课题拟由此深入探讨CSIG促HCC增殖作用的机制, 探讨抑制CSIG以对抗HCC的可能性,为临床HCC的诊治, 解释衰老与肿瘤的关系提供线索。

Understanding of the relationship between carcinogenesis and cell senescence has become an important prerequisite for cancer prevention and treatment. Hepatocellular carcinoma (HCC) is the main type of liver cancer, is one of major causes for death from cancer. Cellular senescence-inhibited gene (CSIG) is a gene cloned by our laboratory, and higher expression in various human young cells and low expression in senescent cells. The CSIG overexpression can significantly delay cell senescence, which depends on the regulation of PTEN translation. We found the CSIG can promote growth of hepatoma cells such as HepG2 and SMMC7721, and the expression of the oncogene c-Myc. Therefore, we will focus on in-depth understanding of the CSIG promoting the proliferation of HCC, to explore the possibility of the suppression the CSIG against HCC in clinical diagnosis and treatment, and finally to provide clues to explain the relationship between aging and tumor.